Sepsis in surgical patients: Personalized medicine in the future treatment of sepsis.

Sepsis results when a severe infection overwhelms the normal regulatory mechanisms of the immune system, resulting in a dysregulated host response characterized by new-onset organ failure. A wide range of infectious challenges can induce sepsis, resulting in an even wider range of maladaptive immune responses. This makes sepsis a syndromic diagnosis without a unifying, underlying molecular mechanism.

Five-Year Sustained Impact of a Thoracic Enhanced Recovery After Surgery Program.

Background: Our thoracic enhanced recovery program (ERP) decreased the use of postoperative morphine equivalents and hospital costs 1 year after implementation at our tertiary center. The sustainability and potential increasing benefit of this program were evaluated.

Methods: From 2015 to 2021, we prospectively analyzed the outcomes of patients who underwent elective pleural, pulmonary, or mediastinal operations at our institution.

[The effect of obesity on the outcome of surgical aortic valve replacement for aortic stenosis].

Introduction: Our objective was to investigate the effect of obesity on short-term complications and long-term survival after surgical aortic valve replacement (SAVR) for aortic stenosis (AS).

Material And Methods: A retrospective study on 748 patients who underwent SAVR for AS in Iceland 2003-2020. Patients were divided into groups based on body mass index (BMI): normal (18.

Immediate and long-term need for permanent cardiac pacing following aortic valve replacement.

Atrioventricular (AV) node conduction disturbances are common following surgical aortic valve replacement (SAVR), and in some cases the patient needs a permanent pacemaker (PPM) implantation before discharge from hospital. Little is known about the long-term need for PPM and the PPM dependency of these individuals. We determined the incidence of PPM implantation before and after discharge in SAVR patients.

Improved long-term outcome of surgical AVR for AS: Results from a population-based cohort.

Background: The aim of this retrospective study was to determine changes in outcomes after surgical aortic valve replacement (SAVR) for aortic stenosis (AS) in Iceland over a 15-year period.

Methods: We included 587 patients who underwent SAVR for AS in Iceland during the period 2002-2016, with a total follow-up of 3245 patient-years. Short-term and long-term outcomes, 30-day mortality, and long-term survival (Kaplan-Meier) were analyzed.

[Early outcome of surgical aortic valve replacement for aortic stenosis in Icelandic females].

Introduction: Aortic valve replacement (AVR) for aortic stenosis (AS) is the second most common open-heart procedure performed in Iceland. The aim of this study was to analyze the early outcome of AVR among females in Iceland.

Materials And Methods: This was a retrospective study including 428 patients who underwent surgical AVR due to AS in Iceland from 2002-2013.

Favorable Survival after Aortic Valve Replacement Compared to the General Population.

Background: A comparison was made between the long-term survival of patients undergoing aortic valve replacement (AVR) for aortic stenosis and of the general Icelandic population, using centralized registries.

Methods: A total of 366 AVR patients (231 males, 135 females; mean age 70.1 years) operated on for aortic stenosis in Iceland between 2002 and 2011 was included in the study.

Acute kidney injury and outcome following aortic valve replacement for aortic stenosis.

Objectives: Most studies on acute kidney injury (AKI) following open-heart surgery have focused on short-term outcome following coronary artery bypass grafting. We reviewed the incidence, risk factors and outcome, including long-term survival, of AKI after aortic valve replacement (AVR) in a population-based cohort.

Methods: A retrospective review of 365 patients who underwent AVR for aortic stenosis during 2002-2011 was made.

[The outcomes of coronary artery bypass and aortic valve replacement in elderly patients].

Objective: To study the outcome of open heart surgery in an increasing population of elderly patients in Iceland.

Material And Methods: A retrospective study of patients (n=876) that underwent coronary artery bypass (CABG) or aortic valve replacement (AVR) for aortic stenosis in Iceland 2002-2006. Complication rates, operative mortality and long-term survival were compared between patients older (n=221, 25%) and younger (n=655, 75%) than 75 years.

[Aortic valve replacement for aortic stenosis in Iceland 2002-2006: Long term complications and survival].

Objective: To investigate long-term complications and survival following aortic valve replacement (AVR) in patients with aortic stenosis (AS) in Iceland.

Material And Methods: Included were 156 patients (average age 71.7 yrs, 64.

[Aortic valve replacement for aortic stenosis in Iceland 2002-2006: Indications and short term complications].

Objective: Information on surgical outcome of aortic valve replacement (AVR) has not been available in Iceland. We therefore studied the indications, short-term complications and operative mortality in Icelandic patients that underwent AVR with aortic stenosis.

Material And Methods: This was a retrospective study including all patients that underwent AVR for aortic stenosis at Landspitali between 2002 and 2006, a total of 156 patients (average age 71.

[Impact of obesity on surgical outcomes following coronary artery bypass graft surgery].

Introduction: Obesity has been related to increased postoperative morbidity and mortality following open-heart surgery. However, recent studies have shown no association or even a more favourable outcome in obese patients. This relationship was investigated in a well-defined cohort of patients that underwent myocardial revascularisation in Iceland.