Propargylic alcohols are one of the readily available and highly explored building blocks in organic synthesis. They show distinct reactivities compared to simple alcohols and/or alkynes, and hence provide diverse possibilities to develop novel synthetic strategies for the construction of polycyclic systems, including heterocycles. The six-membered heterocycles, pyridines, quinolines, and isoquinolines, are very important privileged structures in medicinal chemistry and drug discovery due to their broad spectrum of biological activities.
View Article and Find Full Text PDFAn efficient three-component protocol for the synthesis of trifluoromethylated spiro-isoxazolidine-oxindoles has been developed. This approach employs the 1,3-dipolar cycloaddition of trifluoromethyl nitrone, generated in situ from trifluorodiazoethane and nitrosoarene, with phenacylideneoxindoles. A range of phenacyclideneoxindoles and nitrosoarenes can be subjected to this reaction to generate the spiro-isoxazolidine-oxindole derivatives.
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