Publications by authors named "Sindija Smite"
Article Synopsis
- CD8 T cells are crucial for the immune response against infections and tumors, and their proliferation is stimulated by dendritic cells (DCs).
- This study reveals that products released from thapsigargin-stimulated mast cells impair the ability of DCs to induce CD8 T-cell proliferation and Th1 cytokine production.
- While thapsLAD2-matured DCs show some maturation markers, they produce no detectable TNF or IL-12 and are less effective than R848-matured DCs in promoting CD8 T-cell proliferation, highlighting a new way mast cells can regulate immune responses.
The immune checkpoint inhibitors have revolutionized cancer immunotherapy. These inhibitors are game changers in many cancers and for many patients, sometimes show unprecedented therapeutic efficacy. However, their therapeutic efficacy is largely limited in many solid tumors where the tumor-controlled immune microenvironment prevents the immune system from efficiently reaching, recognizing, and eliminating cancer cells.
View Article and Find Full Text PDFBackground: Antibody response to SARS-CoV-2 is a valuable biomarker for the assessment of the spread of the virus in a population and evaluation of the vaccine candidates. Recent data suggest that antibody levels also may have a prognostic significance in COVID-19. Most of the serological studies so far rely on testing antibodies against spike (S) or nucleocapsid (N) protein, however antibodies can be directed against other structural and nonstructural proteins of the virus, whereas their frequency, biological and clinical significance is unknown.
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