Publications by authors named "Sindija Papirte"
Article Synopsis
- * The study involved 140 CSU patients primarily comprising females with a mean age of 41.3, with many experiencing associated symptoms and identifiable triggers; 85.7% were treated with second-generation antihistamines.
- * Results indicated severe disease in a substantial portion of patients, with poor control over symptoms and a notable impact on mental health, stressing the need for improved patient care and further research on treatment efficacy.
Predominantly antibody deficiencies (PADs) are inborn disorders characterized by immune dysregulation and increased susceptibility to infections. Response to vaccination, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may be impaired in these patients, and studies on responsiveness correlates, including cytokine signatures to antigen stimulation, are sparse. In this study, we aimed to describe the spike-specific cytokine response following whole-blood stimulation with SARS-CoV-2 spike peptides in patients with PAD ( = 16 with common variable immunodeficiency and = 15 with selective IgA deficiency) and its relationship with the occurrence of coronavirus disease 2019 (COVID-19) during up to 10-month follow-up period.
View Article and Find Full Text PDFSome studies have found increased coronavirus disease-19 (COVID-19)-related morbidity and mortality in patients with primary antibody deficiencies. Immunization against COVID-19 may, therefore, be particularly important in these patients. However, the durability of the immune response remains unclear in such patients.
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