Publications by authors named "Sindhu Pandurangi"
Background: Matrix metalloproteinase 7 (MMP-7) is a novel biomarker for diagnosis of biliary atresia (BA), the most common cholestatic liver disease in infancy. There is a pressing need to determine the utility of MMP-7 levels in infants with congenital heart disease (CHD) to avoid unnecessary invasive diagnostic procedures in this high-risk population. We investigated the utility of MMP-7 in discriminating BA from non-BA cholestasis in infants with CHD and whether MMP-7 elevation was present in infants requiring treatment for clinically significant PH.
View Article and Find Full Text PDFBackground: Matrix metalloproteinase 7 (MMP-7) is a novel biomarker for diagnosis of biliary atresia (BA), the most common cholestatic liver disease in infancy. There is a pressing need to determine the utility of MMP-7 levels in infants with congenital heart disease (CHD) to avoid unnecessary invasive diagnostic procedures in this high-risk population. We investigated the utility of MMP-7 in discriminating BA from non-BA cholestasis in infants with CHD and whether MMP-7 elevation was present in infants requiring treatment for clinically significant PH.
View Article and Find Full Text PDFArticle Synopsis
- High serum levels of matrix metalloproteinase-7 (MMP-7) have been identified as a potential diagnostic biomarker for biliary atresia (BA) in infants with cholestasis, showing strong accuracy in a large North American study.
- MMP-7 demonstrated a high area under the receiver operating characteristic (AUROC) score of 0.90, with a sensitivity of 94.03% and a specificity of 77.78% at a cutoff of 52.8 ng/mL, outperforming other clinical markers such as gamma-glutamyl transferase.
- Results support using MMP-7 in clinical settings to improve diagnostic efficiency for BA, as cutoff values vary with different
Background: Controversies in management of biliary atresia (BA) after hepatoportoenterostomy (HPE) lead to variable treatment protocols. We implemented standardized medical management after HPE, customizing the use of antibiotics and corticosteroids based on patient-specific factors.
Methods: In this retrospective analysis, 20 consecutive infants underwent HPE for BA and were compared to a historical cohort.
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View Article and Find Full Text PDFBackground: Advocacy regarding child health policy is a core tenet of pediatrics. Previous research has demonstrated that most pediatric providers believe collective advocacy and political involvement are essential aspects of their profession, but less is known about how pediatric providers engage with families about policy issues that impact child health. The objectives of this study were to examine providers' perceptions and practices with regards to discussing health policy issues with families and to identify provider characteristics associated with having these discussions.
View Article and Find Full Text PDFPurpose: (1) To characterise changes in dead space fraction during the first 120 post-operative hours in neonates undergoing stage 1 palliation for hypoplastic left heart syndrome, including hybrid procedure; (2) to document whether dead space fraction varied by shunt type (Blalock-Taussig shunt and Sano) and hybrid procedure; and (3) to determine the association between dead space fraction and outcomes.
Methods: Retrospective chart review in neonates undergoing stage 1 palliation for hypoplastic left heart syndrome in a cardiac intensive care unit over a consecutive 30-month period. A linear mixed model was used to determine the differences in dead space over time.