Unravelling the impact of epigenetic mechanisms on offspring growth, production, reproduction and disease susceptibility.

Epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNA molecules, play a critical role in gene expression and regulation in livestock species, influencing development, reproduction and disease resistance. DNA methylation patterns silence gene expression by blocking transcription factor binding, while histone modifications alter chromatin structure and affect DNA accessibility. Livestock-specific histone modifications contribute to gene expression and genome stability.

Thin Films of MOF-on-Guest@MOF: A Simple Strategy of Designing Electronic Heterostructures.

Depositing thin films of pristine metal-organic framework (MOF) on top of a lattice-matched and molecularly doped MOF could provide a new path for generating electronic heterostructures of MOFs with well-defined interfaces. Herein, the CuBTC (top-layer)/TCNQ@CuBTC (bottom-layer) system is fabricated by sequential deposition on a functionalized Au substrate, and clear-cut rectification of electrical current across the thin film was observed at room-temperature. Interestingly, the electrical current rectification ratio (RR) was found to be significantly influenced by the effect of temperature (400 K), resulting in a remarkable figure in the domain of MOFs.

Extraction and chemical characterisation of agro-waste from turmeric leaves as a source of bioactive essential oils with insecticidal and antioxidant activities.

Turmeric (Curcuma longa L.) is a significant crop that has historically been used worldwide as a medicinal plant, spice, food colouring agent, and a significant ingredient in cosmetic industries. After harvesting rhizomes, leaves are considered waste material.

Insulator-to-metal-like transition in thin films of a biological metal-organic framework.

Temperature-induced insulator-to-metal transitions (IMTs) where the electrical resistivity can be altered by over tens of orders of magnitude are most often accompanied by structural phase transition in the system. Here, we demonstrate an insulator-to-metal-like transition (IMLT) at 333 K in thin films of a biological metal-organic framework (bio-MOF) which was generated upon an extended coordination of the cystine (dimer of amino acid cysteine) ligand with cupric ion (spin-1/2 system) - without appreciable change in the structure. Bio-MOFs are crystalline porous solids and a subclass of conventional MOFs where physiological functionalities of bio-molecular ligands along with the structural diversity can primarily be utilized for various biomedical applications.

Charge-transfer interface of insulating metal-organic frameworks with metallic conduction.

Downsizing materials into hetero-structured thin film configurations is an important avenue to capture various interfacial phenomena. Metallic conduction at the interfaces of insulating transition metal oxides and organic molecules are notable examples, though, it remained elusive in the domain of coordination polymers including metal-organic frameworks (MOFs). MOFs are comprised of metal centers connected to organic linkers with an extended coordination geometry and potential void space.

Value-driven career attitude and job performance: An intermediary role of organizational citizenship behavior.

Background: Value-driven career attitude (VDCA) is considered a dimension of a protean career attitude (PCA). Individuals with this attitude seek out personally meaningful experiences and set their own psychological career success standards. This study investigates the association between value-driven career attitude and job performance.

Influence of sodium caseinate, maltodextrin, pectin and their Maillard conjugate on the stability, in vitro release, anti-oxidant property and cell viability of eugenol-olive oil nanoemulsions.

The influence of protein (sodium caseinate-SC), polysaccharide (maltodextrin-MD; pectin-PC) and their Maillard conjugates (sodium caseinate maltodextrin conjugate-SCMDC; sodium caseinate pectin conjugate-SCPCC) were studied on the physico-chemical and biological properties of eugenol nanoemulsions/powder. The chemical composition was optimized using Taguchi design. The particles size of eugenol nanoemulsions with SC, MD, PC, SCMDC and SCPCC were 104.

Direct Layer-by-Layer Growth of Crystalline Ag-TCNQ Thin Films on Functionalized Au Substrate: How Critical Is the pH of Ag(I) Solution?

Wet-chemical fabrication of a crystalline Ag-TCNQ (TCNQ = 7,7,8,8-tetracyanoquinodimethane) thin film on non-Ag substrate is challenging whereby the chemistry was powered by photon energy and/or electrical energy. We report for the first time, direct chemical growth of a Ag-TCNQ thin film on a functionalized Au substrate by employing the layer-by-layer (LbL) approach at ambient reaction conditions. Various Ag(I) salt precursors previously realized to be unsuitable for the fabrication of Ag-TCNQ thin films on non-Ag substrates ultimately gave rise to dense and uniform thin films of Ag-TCNQ.

CT appearance of gastrointestinal tract mucormycosis.

Mucormycosis is a fungal infection caused by fungi of order mucorales. It is most commonly seen in patients with an impaired immune system due to any cause. Gastrointestinal mucormycosis is the least frequent type and may be a primary disease or a feature of generalized mucormycosis.

Emergent Interface in Heterostructured Thin Films of Cu(II) and Cu(I) Coordination Polymers.

In this work we report fabrication of high-quality AB- and BA-type heterostructured thin films of cubic Cu(II) (A-type) and tetragonal Cu(I) (B-type) coordination polymers (CPs) on the functionalized Au substrate by the layer-by-layer method. Successful growth of Cu(I)-CP on top of Cu(II)-CP was assigned to be due to the interfacial reduction reaction (IRR). Notably, electrical transport measurements across AB- and BA-type heterostructured thin films revealed rectification of current in opposite directions.

Perspective on the Interfacial Reduction Reaction.

Chemical reactions involving oxidation and reduction processes at interfaces may vary from those in conventional liquid-phase or solid-phase reactions and could influence the overall outcome. This article primarily features a study on metal-ligand coordination at the solid-liquid interface. Of particular mention is the spontaneous reduction of Cu(II) to Cu(I) at a solid-liquid interface without the need of any extraneous reducing agent, unlike in the liquid-phase reaction whereby no reduction of Cu(II) to Cu(I) took place.

Prognostic Factors of Mortality among Adult Patients on Antiretroviral Therapy in India: A Hospital Based Retrospective Cohort Study.

Introduction: HIV related deaths still continue to occur in large numbers in spite of good quality drugs being freely available in India. This study was therefore done to assess the prognostic factors of mortality among people living with HIV (PLHIV) on antiretroviral therapy (ART). This would help in planning strategies for further improving their survival.

Duloxetine loaded-microemulsion system to improve behavioral activities by upregulating serotonin and norepinephrine in brain for the treatment of depression.

Duloxetine is a well-known antidepressant molecule which is used in the treatment of depression but due to poor solubility it suffers with the drawback of low oral bioavailability. The objective of present work was to formulate and characterize duloxetine loaded microemulsion to enhance the oral bioavailability. Prepared microemulsion was studied for droplet size, zeta potential, refractive index, polydispersity index (PDI), percentage transmittance, viscosity and in vitro release study.

Correlation of Skin Changes with Hormonal Changes in Polycystic Ovarian Syndrome: A Cross-sectional Study Clinical Study.

Background: Polycystic ovarian syndrome (PCOS) is a heterogenous collection of signs and symptoms that when gathered, form a spectrum of disorder with disturbance of reproductive, endocrine and metabolic functions.

Aim: The aim of this study is to correlate the skin manifestations with hormonal changes and to know the incidence and prevalence of skin manifestations in patients with PCOS.

Materials And Methods: A total of 40 patients with PCOS were examined during 1 year time period from May 2008 P to May 2009.

Unusual presentation of cutaneous leishmaniasis.

Two patients with mini-volcano type of skin lesions which showed histopathologic features of cutaneous leishmaniasis (CL) have been described. It was localised and linear in one case while widespread in the other. Both responded to sodium stibogluconate.

Haemolysin test for characterization of immune ABO antibodies.

Background & Objectives: Antibodies with haemolytic properties are common within the ABO system. These lytic antibodies are immunoglobulin G (IgG) and in high titres cause haemolysis during blood transfusion. Information on Immunoglobulin types and concentration of ABO haemolysins in Indian population is lacking.

Correlation of age and birth order of parents with chromosomal anomalies in children.

One hundred children with suspected congenital and/or malformation and their parents who reported to SAT hospital, Medical College, Trivandrum, India formed the test group. Fifty children with no obvious anomalies or abnormalities and their parents formed the control group. The criteria for selection of the control was 1) the maternal age at delivery was below 30 years and 2) the parents belong to 1st or 2nd birth order.