Basic Science and Pathogenesis.

Background: Early detection and accurate forecasting of AD progression are crucial for timely intervention and management. This study leverages multi-modal data, including MRI scans, brain volumetrics, and clinical notes, utilizing Machine Learning (ML), Deep Learning (DL) and a range of ensemble methods to enhance the forecasting accuracy of Alzheimer's disease.

Method: We utilize the OASIS-3 longitudinal dataset, tracking 1,098 patients over 30 years.

A Marked Poisson Process Driven Latent Shape Model for 3D Segmentation of Reflectance Confocal Microscopy Image Stacks of Human Skin.

Segmenting objects of interest from 3D data sets is a common problem encountered in biological data. Small field of view and intrinsic biological variability combined with optically subtle changes of intensity, resolution, and low contrast in images make the task of segmentation difficult, especially for microscopy of unstained living or freshly excised thick tissues. Incorporating shape information in addition to the appearance of the object of interest can often help improve segmentation performance.

Extensive rewiring of epithelial-stromal co-expression networks in breast cancer.

Background: Epithelial-stromal crosstalk plays a critical role in invasive breast cancer pathogenesis; however, little is known on a systems level about how epithelial-stromal interactions evolve during carcinogenesis.

Results: We develop a framework for building genome-wide epithelial-stromal co-expression networks composed of pairwise co-expression relationships between mRNA levels of genes expressed in the epithelium and stroma across a population of patients. We apply this method to laser capture micro-dissection expression profiling datasets in the setting of breast carcinogenesis.