The Missing Link in Antiamyloid Therapy.

Alzheimer's disease (AD) impacts millions of elderly adults worldwide causing cognitive decline and severe deterioration of activities of daily life. The popular causal hypotheses for several decades include beta-amyloid (Aβ) deposition and tau hyperphosphorylation. AD research and more than 34% of clinical trials in AD are based on these two hypotheses.

Comparative Study on Elder Abuse and Neglect Among Geriatric Population in the Rural and Urban Field Practice Areas of a Medical College.

Background: Elder abuse is a multidimensional problem of public importance. According to the World Health Organization (WHO), 16% of older people were victims of elder abuse. A study conducted by HelpAge India in 2018 showed that Mangaluru ranks the highest in elder abuse (47%).

Evaluation of antimicrobial efficacy of immunoglobulin Y (IgY) against periodontal biofilm.

Background And Objectives: To determine the action of immunoglobulin Y (IgY) on supragingival microbiota and on subgingival microbiota in patients with gingivitis and periodontitis through microbial reduction assay.

Methodology: 40 systemically healthy patients were divided into two groups (gingivitis and periodontitis) with 20 patients per group. Supragingival and subgingival plaque samples were collected from each patient in Group I and Group II, respectively.

Atypical Cutaneous Lymphoid Hyperplasia of Nose: A Pathological Puzzle.

Atypical cutaneous lymphoid hyperplasia is a rare tumour of the head and neck which represents a lymphoproliferative continuum and mimics cutaneous lymphoma. Hereby reporting the case of a 40-year-old gentleman who presented with a swelling over dorsum of nose. On evaluation, Fine needle aspiration cytology was inconclusive with only inflammatory cells.

Femoral Artery Injuries in Closed Femur Shaft Fractures: Case Report.

 Two young male patients, sustained injury to the superficial femoral artery (SFA) following a closed femur shaft fracture. The arterial injuries were confirmed by computed tomography angiography and both underwent fracture fixation and on SFA exploration; a thrombosed arterial segment was noted at the fracture site, addressed with arteriotomy and thrombectomy to restore the vascularity. At 1-year follow-up, both patients had good union at the fracture site and a well-perfused limb.

Pediatric Asthma: Prevalence and Socio-Cultural Factors Affecting Asthma Management in a Rural Area of Northern Karnataka.

Context: Asthma prevalence and severity is increasing among Indian children. There is the paucity of data on pediatric asthma in rural India and treatment received by asthmatics is not up-to-standard treatment guidelines.

Aim: The aim is to estimate asthma prevalence and factors influencing access to standard asthmatic care among 5-15 years aged children.

Longitudinal Serology of SARS-CoV-2-Infected Individuals in India: A Prospective Cohort Study.

Clinical and epidemiological characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now widely available, but there are few data regarding longitudinal serology in large cohorts, particularly those from low-income and middle-income countries. We established an ongoing prospective cohort of 3,840 SARS-CoV-2-positive individuals according to RT-PCR in the Delhi-National Capital Region of India to document clinical and immunological characteristics during illness and convalescence. The immunoglobulin G (IgG) responses to the receptor binding domain (RBD) and nucleocapsid were assessed at 0 to 7 days, 10 to 28 days, and 6 to 10 weeks after infection.

Biochemical and nutritional characterization of dragon fruit (Hylocereus species).

Nutritional and biochemical composition of dragon fruit (Hylocereus) species H. undatus (fruits with white pulp and pink skin), and H. polyrhizus (fruits with red pulp and pink skin) were investigated to develop the nutritional composition data for dragon fruit and compare the difference between H.

Endoxifen: A new, protein kinase C inhibitor to treat acute and mixed mania associated with bipolar I disorder.

Objectives: Endoxifen is a protein kinase C inhibitor. The objective of the present phase III study was to demonstrate the safety and efficacy of endoxifen in treating bipolar I disorder (BPD I) patients.

Methods: A multicenter, double-blind, active-controlled study was conducted using a daily dose of 8 mg endoxifen compared to 1000 mg divalproex, the current standard treatment, in patients with BPD I acute manic episodes with/without mixed features.

A scalable, self-sustaining model for screening and treatment of diabetic retinopathy in rural Karnataka.

The Indian health infrastructure is struggling to handle the burgeoning number of people with diabetes. Managing the complications of diabetes in an organized manner through the government health programs is still a distant reality. Here, we describe a program aimed at addressing the problem of diabetic retinopathy in rural areas of Tumkur district in Karnataka.

Hand-Grip Strength: Normative Reference Values and Equations for Individuals 18 to 85 Years of Age Residing in the United States.

Background Hand-grip strength is an indicator of overall strength and a predictor of important outcomes. Up-to-date, population-specific reference values for measurements of grip strength are needed to properly interpret strength outcomes. Objectives To provide population-based grip-strength reference values and equations for US residents 18 to 85 years of age.

Summary of grip strength measurements obtained in the 2011-2012 and 2013-2014 National Health and Nutrition Examination Surveys.

Study Design: Cross-sectional and descriptive study.

Introduction: Supported by the Centers for Disease Control and Prevention, the National Health and Nutrition Examination Survey (NHANES) began collecting grip strength data from nationally representative samples in 2011.

Purpose Of The Study: To examine the stability of the grip strength values across 2 data release cycles and provide updated US population-based grip strength values for 6 to 80 year olds.

Global rating of change: perspectives of patients with lumbar impairments and of their physical therapists.

: Global rating of change (GROC) scores provide a means of measuring patients' self-perceived change in health status over time. : The purposes of the study were to examine agreement of GROC ratings between the patient (GROCp) and the treating therapist (GROCt), the impact on the minimal clinically important difference (MCID) estimates by reporting resources, and the relationships between the subjective GROC scores and objective outcome measures. : Data from 52,767 patients with orthopedic lumbar spine impairments treated in 623 outpatient rehabilitation clinics in 34 states (United States) were analyzed.

Rasch Analysis of the Activities-Specific Balance Confidence Scale in Older Adults Seeking Outpatient Rehabilitation Services.

Background The Activities-specific Balance Confidence (ABC) scale measures confidence in performing various ambulatory activities without falling or experiencing a sense of unsteadiness. Objectives This study (1) examined the ABC scale (0-100) using Rasch analysis, (2) assessed statistically reliable change, and (3) developed a functional staging to guide clinical interpretation of a patient's improvement. Methods The authors examined rating-scale structure, item difficulty hierarchy, item fit, person-item match, separation index, differential item functioning, test precision, and unidimensionality.

Neural Substrate of Group Mental Health: Insights from Multi-Brain Reference Frame in Functional Neuroimaging.

Contemporary mental health practice primarily centers around the neurobiological and psychological processes at the individual level. However, a more careful consideration of interpersonal and other group-level attributes (e.g.

Identifying sincerity of effort based on the combined predictive ability of multiple grip strength tests.

Study Design: Retrospective Cohort.

Introduction: Detecting sincerity of effort (SOE) of grip strength remains a frustrating and elusive task for hand therapists because there are no valid, reliable, or widely accepted assessments for identifying feigned effort. Some therapists use various combinations of different SOE tests in an attempt to identify feigned effort, but there is lack of evidence to support this practice.

Alcoholic delirium tremens with hollow viscus perforation scheduled for emergency laparotomy.

Alcohol is a drug consumed at some time in life by up to 80% of the population according to western statistics. Wide differences in socioeconomic status in India contribute to various degrees and severity of alcoholism and its associated complications. The symptoms of alcohol withdrawal range from such minor ones as insomnia and tremulousness to severe complications such as withdrawal seizures and delirium tremens.

Influence of fear-avoidance beliefs on functional status outcomes for people with musculoskeletal conditions of the shoulder.

Background: The influence of elevated fear-avoidance beliefs on change in functional status is unclear.

Objective: The purpose of this study was to determine the influence of fear-avoidance on recovery of functional status during rehabilitation for people with shoulder impairments.

Design: A retrospective longitudinal cohort study was conducted.

Using the "visual target grip test" to identify sincerity of effort during grip strength testing.

Unlabelled: We devised a sincerity of effort assessment based on "tricking" a person into exerting maximal effort by providing incorrect visual feedback. The assessment involves deriving a target line from nonvisual peak gripping force, instructing participants to reach it with each grip repetition, and then secretly changing its position, which requires doubling the force necessary to reach it. Accordingly, participants are tricked into exerting more force than intended to reach the deceptive target line.

Validity, reliability, and responsiveness of a digital version of the visual analog scale.

Unlabelled: The design used in this study was a prospective cohort. Pain intensity levels recorded by the digital version of the visual analog scale (VAS-D) are easy to both score and share with other health care professionals. The purpose of the study was to examine the test-retest reliability, concurrent validity, and responsiveness of the VAS-D.