Publications by authors named "Sindduja Muthukumar"
J Biochem Mol Toxicol
June 2024
Article Synopsis
- Alzheimer's disease (AD) is a progressive condition affecting cognitive abilities and daily activities, with no known cure and variable progression rates.
- Recent research highlights that heavy metals may contribute significantly to AD development by affecting epigenetic alterations, which could lead to new therapeutic strategies.
- The review focuses on the specific roles of metals like cadmium, iron, arsenic, copper, and lithium in AD pathology, encouraging further research on their epigenetic effects and the potential for developing diagnostic tools and treatments.
Article Synopsis
- The study investigates the relationship between lifestyle factors (like smoking and alcohol) and the KMO gene’s impact on Parkinson's Disease (PD) risk, focusing on a sample of 164 participants, half with PD and half healthy.
- Clinical assessments showed significant impairments in late-onset PD cases, particularly in the areas of smell, tremors, and walking stability.
- Genetic analysis identified specific variants in the KMO gene linked to changes in levels of kynurenic acid and 3-hydroxykynurenine, suggesting these changes may offer protective effects against disease progression.
