Publications by authors named "Sinclair S"

Compassion is recognized as a key component of high-quality healthcare. The literature shows that compassion is essential to improving patient-reported outcomes and fostering health care professionals' (HCPs) response and resilience to burnout. However, compassion is inherently difficult to define, and a validated tool to reliably quantify and measure patients' experience of compassion in healthcare settings did not exist until recently.

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  • Overactive bladder (OAB) is a long-term condition affecting health and finances, and guidelines were created to improve its management, but the effectiveness of these guidelines remains unclear.
  • A study analyzed data from a national health claims database (Optum) between 2013 and 2018 to evaluate trends in OAB treatment, focusing on medication and minimally invasive therapies post-2014 guideline updates.
  • The research included over 1.8 million patients, revealing a significant increase in new OAB diagnoses (369%) and providing insights into therapy utilization patterns based on various demographic factors.
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Purpose: Multiple myeloma is an incurable hematologic cancer. A palliative approach to care can be used in conjunction with curative therapy to alleviate suffering, but is underutilized in the hemato- oncology population. The purpose of this study was to explore living with multiple myeloma and individuals' experiences with, and perceptions of a palliative approach in their care.

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Objectif: Le myélome multiple est un cancer hématologique incurable. Pour alléger la souffrance, il est possible d'employer une approche palliative en conjonction avec un traitement curatif, mais cette approche est sous-utilisée chez les patients en hémato-oncologie. L'objectif de la présente étude est d'examiner l'expérience des personnes atteintes d'un myélome multiple qui reçoivent un traitement palliatif dans le cadre de leurs soins, et de comprendre comment ils perçoivent cette approche.

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When people talk about their healthcare experience, compassion is often a common ingredient in the stories they share. After a decade of healthcare reforms and research on compassion, the experience of receiving compassionate care has been shown to be important to patients and their families. Yet, there is little guidance to inform compassionate practice in the context of providing mental health care.

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Background: Regular exercise can mitigate side effects of cancer treatment. However, only a small proportion of adults with cancer meet exercise guidelines, and older adults (> 65 years) are underrepresented in cancer rehabilitation research. Peer support facilitates health-promoting behaviours in general populations, but interventions merging exercise and peer support for older adults with cancer are not examined.

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Hepatitis B and Hepatitis C are viral causes of Hepatitis that lead to significant worldwide mortality and morbidity through the sequelae of fibrosis and hepatocellular carcinoma. In this review, we have summarized recent studies that have examined the effects of antiviral therapy on the regression of fibrosis and the reduction in mortalities associated with the viruses. Antiviral therapy significantly decreases mortality and induces the regression of fibrosis.

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Background: Individuals with transhumeral limb loss have an increased risk of falling, potentially resulting from altered upper-body kinematics during gait. The purpose of this study was to investigate whole-body angular momentum as a measure of movement control, to gain an understanding of how these upper-body kinematics contribute to dynamic balance.

Methods: Eight participants with transhumeral limb loss and eight able-bodied control participants completed three gait trials at self-selected speeds.

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  • The Sinclair Compassion Questionnaire (SCQ) was developed to assess patients' experiences of compassion in palliative care, specifically for those with terminal illnesses.
  • The validation study of the Italian version, SCQit, confirmed its reliability and identified factors such as hospital setting and religious faith that influence compassion experiences among patients.
  • This validated tool can be utilized in clinical practice and research to enhance compassionate care for terminally ill cancer patients and improve healthcare professional training.
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Background: Across Canada, Child Protection Services (CPS) disrupt Indigenous families by apprehending their children at alarmingly high rates. The harms borne by children in out-of-home care (OoHC) have been extensively documented. We examined the impact of OoHC on Manitoba children's health and legal system outcomes to provide rigorous evidence on how discretionary decision-making by CPS agencies can affect these outcomes.

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Formation of organs and specialized tissues in embryonic development requires migration of cells to specific targets. In some instances, such cells migrate as a robust cluster. We here explore a recent local approximation of non-local continuum models by Falcó et al.

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  • Diabetes during pregnancy can cause health problems for both mothers and babies, especially in certain groups like Pacific and Maaori families.
  • After giving birth, many mothers don't get enough extra support for their diabetes, so researchers want to find out what they need to help them and their families better.
  • Through interviews with 19 parents, the study found that balancing professional care with personal needs, having culturally specific support, involving family, and recognizing the ongoing impact of diabetes on mental health are very important.
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Aims And Objectives: This systematic review aims to: (1) explore which tools have been used in Spanish to measure compassion; (2) know which of these tools could be used to assess compassion in healthcare settings from the perspective of patients; (3) evaluate the quality of these patient-reported measures in Spanish contexts; and (4) determine which of these instruments would be best suited to be used in healthcare settings.

Background: Compassion has been recognized as a fundamental dimension of quality healthcare.

Methods: Several scientific databases were consulted for relevant records published up to December 16, 2021.

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Objective: To describe the prevalence of frailty among Medicare beneficiaries with overactive bladder (OAB), analyze oral therapy patterns, and examine potential disparities in treatment.

Methods: This retrospective cohort study utilized the 20% Research Identifiable File Medicare Part D prescription claims dataset (2013-2018). Using the Claims-Based Frailty Index (CFI), Medicare beneficiaries ≥65 years old with OAB were categorized as not frail (CFI <0.

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  • - The study compares the time burden of subcutaneous (SC) versus intravenous (IV) drug administration of trastuzumab and pertuzumab in breast cancer patients, aiming to improve their quality of life during treatment.
  • - Results from 22 enrolled patients showed that SC administration significantly reduced the time patients spent in the treatment chair by an average of 61.8 minutes and total treatment experience time by 81.8 minutes compared to IV.
  • - The findings suggest that SC administration not only shortens patient time commitment but also enhances workflow efficiency for healthcare professionals, making the treatment process more manageable for patients.
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Objective: To examine the unique contribution of patient reported experiences of compassion to overall patient quality care ratings. Additionally, we assess whether patients' reported experiences of compassion in the emergency department differed between sociodemographic groups.

Methods: Provincial data for this cross-sectional study were collected from 03/01/2022 to 09/05/2022 from 14 emergency departments in Alberta, Canada.

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The science of diabetes care has progressed to provide a better understanding of the oxidative and inflammatory lesions and pathophysiology of the neurovascular unit within the retina (and brain) that occur early in diabetes, even prediabetes. Screening for retinal structural abnormalities, has traditionally been performed by fundus examination or color fundus photography; however, these imaging techniques detect the disease only when there are sufficient lesions, predominantly hemorrhagic, that are recognized to occur late in the disease process after significant neuronal apoptosis and atrophy, as well as microvascular occlusion with alterations in vision. Thus, interventions have been primarily oriented toward the later-detected stages, and clinical trials, while demonstrating a slowing of the disease progression, demonstrate minimal visual improvement and modest reduction in the continued loss over prolonged periods.

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  • Compassion is linked to better patient outcomes, quality care, and provider wellbeing, and the EnACT program aims to enhance compassion in healthcare providers through a comprehensive training initiative to address current gaps in education and evaluation tools.
  • The study utilized surveys and qualitative interviews with 26 healthcare providers to assess their experiences and outcomes before and after the training, focusing on aspects like professional fulfillment, burnout, and compassion competence.
  • Results indicated that learners had high levels of compassion competence and professional fulfillment before training, but showed a significant increase in compassion competence and overall satisfaction after completing the program.
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  • The study used the UK's National Endoscopy Database to evaluate if feedback on polyp detection rates could improve endoscopists' performance during colonoscopies.
  • It involved a randomized trial with 541 endoscopists across 36 centers, where those in the intervention group received monthly performance reports based on behavior change theories.
  • Although there was no significant increase in the average number of polyps detected, there were notable improvements in overall polyp detection rates during the intervention, particularly among those who actively engaged with the feedback, but these gains did not carry over after the intervention.
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  • The study evaluates the effectiveness of targeted agents, specifically pertuzumab plus trastuzumab, in patients with advanced biliary tract cancer (BTC) who have specific genomic alterations.
  • Out of 29 enrolled patients, the treatment showed a 40% disease control rate, with some experiencing significant responses, indicating potential benefits of this combination therapy.
  • Although the treatment was generally well-received, a few patients reported notable adverse events, highlighting the importance of monitoring safety alongside treatment efficacy.
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Background: Transhumeral (TH) limb loss leads to loss of body mass and reduced shoulder range of motion. Despite most owning a prosthesis, prosthesis abandonment is common. The consequence of TH limb loss and prosthesis use and disuse during gait may be compensation in the upper body, contributing to back pain or injury.

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The objective of this study was to define targeted reaching performance without visual information for transhumeral (TH) prosthesis users, establishing baseline information about extended physiological proprioception (EPP) in this population. Subjects completed a seated proprioceptive targeting task under simultaneous motion capture, using their prosthesis and intact limb. Eight male subjects, median age of 58 years (range 29-77 years), were selected from an ongoing screening study to participate.

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  • - Genomic tumor testing (GTT) aims to identify specific tumor variants that can be treated with targeted drugs, but access is often limited for rural patients in community oncology settings.
  • - In a study involving 1,603 adult cancer patients in Maine, 1,258 had actionable variants identified, leading to 240 genome-matched treatments, with a notable survival benefit for those treated (31% less likely to die within one year).
  • - The results indicate that while GTT can provide effective treatment options in rural areas, there is still a need to increase the availability of clinical trials and improve the infrastructure supporting these tests.
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The need for more people to register as organ donors is a pressing concern. This preregistered experiment examined whether portraying a patient in need of an organ transplant as leading a healthy lifestyle (an "innocent victim") can serve to increase people's intentions to register as post-mortem organ donors. Participants not previously registered as organ donors (N = 348) were randomly assigned to an innocent identified victim, non-innocent identified victim, or statistical victims condition.

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