Publications by authors named "Sina Upheber"
Article Synopsis
- Loss of KAI1, a tumor-suppressor protein, is linked to worse outcomes in cancer patients, especially as its presence diminishes in metastases.
- KAI1 interacts with integrin αvβ3 to inhibit ovarian cancer cell behavior, while a variant called KAI1-splice exhibits the opposite effect by promoting cell migration and proliferation.
- The KAI1-splice variant not only diminishes KAI1's tumor-suppressive capabilities but also enhances functions that favor tumor growth and spread due to increased signaling through the epidermal growth factor receptor.
