Central Proteins of Plasma in Response to Low-Level Laser Therapy Involve in Body Hemostasis and Wound Repair.

Low-level laser therapy (LLLT) is accompanied by protein expression change in the body. There are many efforts to find a clear relationship between the differentially expressed proteins. This study aims to find the central differentiated expressed proteins of plasma after LLLT.

Introducing GATA3 as a prominent player in Crohn's disease.

Aim: This study was aimed at gene assessment of Crohn's disease (CD) through protein-protein interaction (PPI) network analysis to find crucial genes.

Background: CD is a major subtype of inflammatory bowel diseases (IBD), which affects gastrointestinal tract. PPI network analysis is a suitable tool to clarify a critical gene as a drug target or diagnostic biomarker for these types of diseases.

Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients.

Aim: To assess the immunological reactions and gene expression level in the celiac disease (CD) patients under a gluten-free diet (GFD).

Background: CD is an autoimmune disorder in genetic susceptible individuals and lifelong gluten free diet is the effective treatment method. It seems that treated patients will experience a normal life style though there are documents about some potential damages.

Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus.

Aim: This study aimed to screen the common genes between celiac disease (CD) and type 1 diabetes mellitus to find critical ones.

Background: Celiac disease is a chronic autoimmune disorder which is correlated to type 1 diabetes mellitus (T1DM) in several molecular pathways. Understanding the clear common molecular mechanism of both diseases is of interest to scientists.

Analysis of Laser Therapy Effects on Squamous Cell Carcinoma Patients: A System Biology Study.

The Mechanism of laser therapy and also its safety are 2 important features of the application of different types of lasers in medicine. This study aims to investigate the critically affected genes after the treatment of squamous cell carcinoma patients. The gene expression profiles of 4 squamous cell carcinoma patients that were treated via chemoradiotherapy (CRT) plus the laser and 3 similar patients without laser exposure from Gene Expression Omnibus (GEO) were downloaded and were screened to find critical genes via network analysis.

Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy.

Laser therapy is known as an efficient approach in dermatology surgery. CO2 laser therapy is a gold standard treatment in skin surgery. This study aimed to evaluate the interferons change after CO2 laser surgery Significant differentially-expressed genes (DEGs) of arm skin after 7 days of treatment by the CO2 laser relative to the controls are downloaded from Gene Expression Omnibus (GEO) and are included in the protein-protein interaction network via a STRING database (an application of Cytoscape software).

The critical role of dysregulation of antioxidant activity and carbohydrate metabolism in celiac disease.

Aim: Identification of the important processes and the related genes that are dis-regulated in the celiac disease (CD) was the aim of this study.

Background: Celiac disease is an autoimmune disorder which is characterized by immune reaction response mostly to wheat gluten. The gluten-free diet is the best-known treatment of the patients.

Highlighted role of VEGFA in follow up of celiac disease.

Aim: Evolution of gene expression change of intestine tissue in celiac patients to find a new molecular prospective of disease is the aim of this study.

Background: Celiac disease (CD) as an autoimmune disease is known as an immune reaction response to the gluten in patients. It is reported that genetic and environmental conditions are important in onset and progress of CD.

Pancreatic adenocarcinoma protein-protein interaction network analysis.

Aim: Gene assessment of pancreatic adenocarcinoma disease via protein-protein interaction (PPI) Network Analysis.

Background: Diagnosis, especially early detection of pancreatic adenocarcinoma as a lethal disease implies more investigation. PPI Network Analysis is a suitable tool to discover new aspects of molecular mechanism of diseases.