Publications by authors named "Sina Jame"
Background: Frequent premature ventricular complexes (PVCs) can cause PVC-induced cardiomyopathy. The value of PVC ablation in patients with preserved left ventricular function in the low-normal range (ejection fraction: 50-55%) is not established. Strain analysis has been used to estimate changes in left ventricular function beyond assessment of the ejection fraction (EF).
View Article and Find Full Text PDFBackground: Left bundle branch block (LBBB) and atrioventricular (AV) conduction abnormalities requiring permanent pacemaker (PPM) implantation occur frequently following transcatheter aortic valve replacement (TAVR). The resultant left ventricular (LV) dyssynchrony may be associated with adverse clinical events.
Objectives: The purpose of this study was to assess the adverse outcomes associated with LV dyssynchrony due to high-burden right ventricular (RV) pacing or permanent LBBB following TAVR in patients with preserved left ventricular ejection fraction (LVEF).
Background: Lead damage is a complication caused by lead manipulation or heating damage from conventional electrocautery (EC) after cardiovascular implantable electronic device (CIED) replacement. Application of electrical plasma (PEAK PlasmaBlade) is a new technology that reportedly reduces this risk.
Objectives: This study was designed to compare the effect of EC versus PEAK PlasmaBlade on lead parameters and complications after generator replacement procedures.
Article Synopsis
- The study focuses on a modified technique for evaluating bidirectional block of the cavo-tricuspid isthmus (CTI) during ablation procedures for atrial flutter (AFl).
- It involved 62 patients who underwent radiofrequency (RF) ablation, measuring specific intervals to confirm the effectiveness of the CTI block and ensure AFl non-inducibility post-procedure.
- Results showed a successful CTI block with minimal complications; only one patient experienced a recurrence of AFl during the follow-up period of about 16 months.
Article Synopsis
- * Out of 113 patients treated, 45% had their AF successfully terminated, with some also showing improvements in areas like the right atrium (RA).
- * On average, 78% of patients remained free from AF after 24 months without needing antiarrhythmic medications, suggesting the method's effectiveness.
Background: Implanted defibrillators are capable of recording activity data based on company-specific proprietary algorithms. This study aimed to determine the prognostic significance of baseline and decline in device-derived activity level across different device companies in the real world.
Methods: We performed a retrospective cohort study of patients (n = 280) who underwent a defibrillator implantation (Boston, Medtronic, St.
Background: Limited studies are available on the clinical significance of left ventricular (LV) lead polarity in patients undergoing cardiac resynchronization therapy (CRT), with a recent study suggesting better outcomes with LV true bipolar pacing.
Objective: We aimed to determine whether true bipolar LV pacing is associated with reduced mortality in a large, real-life CRT cohort, followed by remote monitoring.
Methods: We analyzed de-identified device data from CRT patients followed by the Boston Scientific LATITUDE remote monitoring database system.
Prevention of stroke and systemic thromboembolism remains the cornerstone for management of atrial fibrillation (AF) and flutter. Multiple risk assessment models for stroke and systemic thromboembolism are currently available. The score, with its known limitations, remains as the recommended risk stratification tool in most major guidelines.
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- Ablation in the left ventricle carries a risk of blood clots, and this study focused on how to manage thromboembolism risk after ventricular tachycardia (VT) ablation in 217 patients.!
- Patients who had extensive ablation received a carefully managed dose of unfractionated heparin followed by 3 months of blood thinners, while those with less extensive ablation were treated with antiplatelet medications.!
- The study found that the thromboembolic and bleeding complications were low regardless of the treatment approach, suggesting the protocol for anticoagulation is effective and that antiplatelet therapy is a viable option for less extensive ablations.!
Background: There are limited data on the prognostic importance of declining activity level in patients with heart failure.
Objective: We aimed to assess the association of reduced activity level with adverse cardiovascular outcomes in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT).
Methods: Final device interrogations from patients enrolled in the MADIT-CRT with cardiac resynchronization devices capable of recording percent daily activity level were assessed.
Background: There are limited data on the significance of left ventricular (LV) lead pacing polarity to predict clinical outcomes.
Objectives: We aimed to determine the association between the LV lead pacing polarity for heart failure (HF) or death and ventricular tachyarrhythmias (VTA) in patients enrolled in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy), receiving a cardiac resynchronization therapy device with implanted cardioverter-defibrillator (CRT-D).
Methods: We retrospectively analyzed LV pacing polarity.
Background: Little is known about the opinions of primary care clinicians regarding the newly released 2013 American College of Cardiology/American Heart Association (ACC/AHA) Guidelines for the Prevention of Primary and Secondary Atherosclerotic Disease. This survey was created to assess the awareness, attitudes, and practices of primary care clinicians on adoption of the new guidelines and to explore obstacles to implementation and suggestions for improving shared decision-making.
Methods: Six hundred practicing clinicians within the San Francisco Bay Area Collaborative Research Network were invited to participate in this cross-sectional, Internet-based pilot survey of primary care clinicians.
Objective: Stem cell therapy for angiogenesis and vascular regeneration has been investigated using adult or embryonic stem cells. In the present study, we investigated the potential of endothelial cells (ECs) derived from human induced pluripotent stem cells (hiPSCs) to promote the perfusion of ischemic tissue in a murine model of peripheral arterial disease.
Methods And Results: Endothelial differentiation was initiated by culturing hiPSCs for 14 days in differentiation media supplemented with BMP-4 and vascular endothelial growth factor.
Milk fat globule epidermal growth factor 8 (Mfge8) is a soluble glycoprotein known to regulate inflammation and immunity by mediating apoptotic cell clearance. Since fibrosis can occur as a result of exaggerated apoptosis and inflammation, we set out to investigate the hypothesis that Mfge8 might negatively regulate tissue fibrosis. We report here that Mfge8 does decrease the severity of tissue fibrosis in a mouse model of pulmonary fibrosis; however, it does so not through effects on inflammation and apoptotic cell clearance, but by binding and targeting collagen for cellular uptake through its discoidin domains.
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