Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy.

Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells. evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT.

Smart delivery of epirubicin to cancer cells using aptamer-modified ferritin nanoparticles.

Epirubicin (Epi) is a chemotherapy agent which is commonly used in treatment of cancers. However, despite being efficient, the tendency to use this drug is declining mostly due to its myocardiopathy and drug-resistance of tumour cells. Such side effects could be prevented using targeted nanocarriers.

Anti-mycobacterial Activity of 22 Iranian Endemic or Rare Plant Extracts Against Multi-drug and Extensively Drug-resistant .

Background: Due to side-effects and low efficacy of common drugs on new resistant strains of Mycobacterium tuberculosis (Mtb), investigation on novel drugs and natural compounds from rich sources of endemic plants is required. Thus, in the present study, the anti-mycobacterial effects of 22 Iranian endemic or rare plant extracts on multi-drug resistance (MDR) and extensively-drug resistance (XDR) Mtb isolates were evaluated.

Methods: Twenty-two Iranian endemic and rare plant species from 9 families were collected and extracted by methanol.