Publications by authors named "Sina Bahraminejad"
Acute cerebral ischemia is a leading cause of death and disability, particularly among old adults. The narrow therapeutic window and risk of hemorrhagic transformation largely limit patient eligibility for the current treatment. The neuroinflammatory signaling pathway involving the prostaglandin E2 (PGE) receptor subtype EP2 has now been clarified to contribute to the secondary neurotoxicity following ischemic stroke.
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- - The study investigates the effects of Miltefosine (MIL) and its modified version, liposomal Miltefosine (NMIL), on fetal organs in the context of leishmaniasis treatment, combining computational predictions and chicken embryo experiments.
- - Using in silico analysis, researchers evaluated the interaction of these drugs with important proteins related to leishmaniasis, and validated their predictions through practical tests that examined gene expression and tissue changes in treated embryos.
- - Findings indicate that NMIL is more effective than MIL in targeting critical leishmaniasis-related proteins and causes fewer harmful effects on vascular growth and increases in degenerative changes, suggesting it may be a safer treatment option for pregnant patients.
Leishmaniasis as a widespread neglected vector-borne protozoan disease is a major public health concern in endemic areas due to 12 million people affected worldwide and 60,000 deaths annually. Several problems and side effects in using current chemotherapies leads to progression of new drug delivery systems against leishmaniasis. For instance, layered double hydroxides (LDHs) so-called anionic clays due to their proper characteristics, have been considered recently.
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