Publications by authors named "Sina Al-Kershi"
Children with Down syndrome are at a high risk of developing transient abnormal myelopoiesis (TAM; synonym: TMD) or myeloid leukemia (ML-DS). While most patients with TAM are asymptomatic and go into spontaneous remission without a need for therapy, around 20% of patients die within the first six months due to TAM-related complications. Another 20-30% of patients progress from TAM to ML-DS.
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- Developing the central nervous system relies on tightly regulated gene expression, with Brg1 being crucial for transcription as part of the SWI/SNF chromatin remodeling complex.
- Research found that the absence of Brg1 in neural stem cells (NSCs) between embryonic days 7.5 and 12.5 led to abnormal structures in the brain areas and significant changes in a part of the eye called the neural retina (NR).
- Furthermore, Brg1 loss resulted in decreased cell survival and altered gene expression, indicating its specific and essential role in NSCs for proper brain and eye development.
HOX genes are highly conserved, and their precisely controlled expression is crucial for normal hematopoiesis. Accordingly, deregulation of HOX genes can cause leukemia. However, despite of intensive research on the coding HOX genes, the role of the numerous long noncoding RNAs (lncRNAs) within the HOX clusters during hematopoiesis and their contribution to leukemogenesis are incompletely understood.
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