Background: Metabolic re-wiring with preferential fatty acid oxidation has been observed in lung cancer cells. Whether the use of trimetazidine, an anti-anginal agent that inhibits fatty acid oxidation, alters clinical outcomes in ischemic heart disease (IHD) patients with lung cancers is unknown.
Methods: We carried out this territory-wide, retrospective cohort study of 279,894 IHD patients prescribed with trimetazidine or long-acting oral nitrates in Hong Kong (population coverage of 7.
Urinary tract infection is a frequent problem after stroke. Although prior scoring systems for UTI after stroke have been developed, we developed a simple scoring system for all types of stroke in our own. The study was designed on retrospective data.
View Article and Find Full Text PDFObjective: This study aimed to analyze the effect of Smart Cancer Care program on the quality of life and ease of chemotherapy continuation in cancer patients and the effect of additional tele-management on frequency of use and satisfaction with the Smart Cancer Care program.
Methods: 'Smart Cancer Care' is a mobile program that allows cancer patients undergoing chemotherapy to report symptoms of adverse events and receive remote management. In this study, patients were randomly assigned to three groups: Group A, who received only classical face-to-face management; Group B, who used the Smart Cancer Care program as addition; and Group C, who used the Smart Cancer Care program and received telephone management.
Biochem Biophys Res Commun
October 2024
Introduction: Specific assays of plasma rivaroxaban level are not always readily available with short turnaround time, which hamper the management of urgent clinical situations. In this study, we aimed to build a predictive formula of plasma rivaroxaban levels from international normalized ratio (INR) value and validated in real world clinical situations.
Methods: Ninety-four patients who were taking rivaroxaban participated in the study.
Building envelope features (BEFs) have attracted more and more attention as they have a significant impact on flow structure and pollutant dispersion within street canyons. This paper conducted CFD numerical models validated by wind-tunnel experiments, to explore the effects of the BEFs on characteristics of the airflow and pollutant distribution inside a symmetric street canyon under perpendicular incoming flow. Three different BEFs (balconies, overhangs, and wing walls) and their locations and continuity/discontinuity structures were considered.
View Article and Find Full Text PDFIntroduction: Acquired hemophilia A (AHA) is a rare bleeding disorder with destruction of factor VIII by autoantibodies. Comprehensive data for Chinese patients are lacking. Predictors of hospital stay have not been investigated.
View Article and Find Full Text PDFT lymphoblastic leukemia (T-ALL) is an aggressive haematolymphoid malignancy comprising 15% of acute lymphoblastic leukemia (ALL). Although its prognosis has improved with intensive chemotherapy, the relapse/refractory disease still carries a dismal prognosis. Thus, there is an urgent need to develop novel therapy for T-ALL.
View Article and Find Full Text PDFAlthough research on rare autoimmune and autoinflammatory diseases has enabled definition of nonredundant regulators of homeostasis in human immunity, because of the single gene-single disease nature of many of these diseases, contributing factors were mostly unveiled in sequential and noncoordinated individual studies. We used a network-based approach for integrating a set of 186 inborn errors of immunity with predominant autoimmunity/autoinflammation into a comprehensive map of human immune dysregulation, which we termed "AutoCore." The AutoCore is located centrally within the interactome of all protein-protein interactions, connecting and pinpointing multidisease markers for a range of common, polygenic autoimmune/autoinflammatory diseases.
View Article and Find Full Text PDFBackground: As outpatient chemotherapy treatment increases, cancer patients receiving chemotherapy spend more time at home. In addition, since the types of chemotherapy are gradually expanding, it will be essential to prepare patient self-management strategies for various chemotherapy-related side effects. This study aimed to develop a platform (called Smart Cancer Care) to implement a chemotherapy side effect management program and to evaluate its feasibility.
View Article and Find Full Text PDFIntroduction: Resting heart rate (HR) and heart rate variability (HRV) have been linked with cognition in the general population and in older individuals. The knowledge of this aspect of heart-brain relationship is relatively absent in older individuals with early Alzheimer's disease (AD) pathology. This study explores relationships of the HR, HRV, and cognition in cognitively healthy individuals with pathological amyloid/tau ratio (CH-PATs) in cerebral spinal fluid (CSF) compared to those with normal ratio (CH-NATs).
View Article and Find Full Text PDFObjectives: To identify barriers and facilitators that influence the implementation of paediatric clinical pharmacy services in Hong Kong public hospitals from physicians' and nurses' perspectives.
Methods: A qualitative study was conducted based on semistructured interviews of physicians and nurses who worked in the field of paediatrics in four public hospitals in Hong Kong. Interviews were held via telephone conversations using spoken Cantonese which were audio recorded, then translated and transcribed directly into English by the research team.
Propolis is a natural resinous mixture produced by bees. It provides beneficial effects on human health in the treatment/management of many diseases. The present study was performed to demonstrate the anti- activity of ethanolic extracts of Propolis samples from Iran.
View Article and Find Full Text PDFMixed-vegetation planting patterns are commonly seen in urban areas for specific reasons like aesthetic, cooling, and particle deposition effects of the vegetation. However, they may have a negative impact on human health by worsening the air quality inside the street canyon due to the decreased air exchange rate. From the view of precise control of pollutant concentration in the sensitive areas of people's concern in the existed street canyons, thirty-four cases with different vegetation planting patterns and pressure loss coefficients (λ) are studied numerically to investigate the effects of vegetation on airflow and pollutant dispersion inside the canyon.
View Article and Find Full Text PDFWith continuous global warming, growing urban population density, and increasing compactness of urban buildings, VD (void deck) street design has become increasingly popular in city planning, especially in tropical countries. However, understanding on traffic pollutant dispersion inside the street canyons with VDs is still at early stage. This paper evaluates quantitatively the effects of VD location and wind direction on the ventilation and traffic pollutant exposure inside the street canyon with VDs.
View Article and Find Full Text PDFWith continuous global warming, growing urban population density, and increasing compactness of urban buildings, the "void deck" street canyon design has become increasingly popular in city planning, especially for urban streets located in tropical areas. Nevertheless, research on traffic pollutant dispersion in street canyons with void decks (VDs) is still at its early stage. This study quantitatively evaluates the effects of void deck height and location on the canyon ventilation and pollutant dispersion in asymmetric street canyons with void decks, and the pollutant exposure risk level for pedestrians and street dwellers.
View Article and Find Full Text PDFIsocitrate dehydrogenase 2 (IDH2) mutations occur in more than 15% of cytogenetically normal acute myeloid leukemia (CN-AML) but comparative studies of their roles in leukemogenesis have been scarce. We generated zebrafish models of IDH2 and IDH2 AML and reported their pathologic, functional and transcriptomic features and therapeutic responses to target therapies. Transgenic embryos co-expressing FLT3 and IDH2 mutations showed accentuation of myelopoiesis.
View Article and Find Full Text PDFThe paper analyses the influence of COVID-19 on Portuguese institutions' intake of international students and their responses to the pandemic. Two dimensions are considered: quantitative impact on international enrolments and higher education institutions' strategies for the recruitment and support of international students. The first dimension is analysed through national statistics and comparison of enrolments over the past five years.
View Article and Find Full Text PDFAccumulation of apixaban in plasma is a major concern in patients with chronic kidney disease (CKD). Studies that investigated plasma apixaban level in CKD patients and its association with clinically significant events are scarce. Patients with CKD Stage 1-4 who were taking apixaban, either 2.
View Article and Find Full Text PDFConfiguration of street canyon and the wind environment have a great influence on the self-ventilation capacity of the canyon, but the couple-effect of these two factors could not be considered in the previous study. The purpose of this study is to clarify the couple effect of street canyon configuration and wind environment on the ventilation and pollutant dispersion inside the street canyon. For this purpose, five wind directions of α = 90°, 60°, 45°, 30°, and 0° (α is the angle between the approaching wind and street canyon) and three canyon configurations (flat, step-up, and step-down canyons) were considered with numerical simulation and wind-tunnel experiment.
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