Publications by authors named "Simsir A"

Article Synopsis
  • TERT promoter mutations are frequently found in thyroid cancers, but their impact on tumor behavior along with other molecular changes is not fully understood.
  • A study of 32 patients revealed that most cases with TERT mutations and additional molecular changes were malignant, particularly high-grade thyroid carcinomas (HGCs).
  • Isolated TERT mutations were more likely linked to benign tumors, while cases with multiple mutations were predominantly associated with malignancy, especially high-grade forms.
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Article Synopsis
  • - The study focuses on the role of fine needle aspiration (FNA) in assessing salivary gland tumors, specifically looking into the “Salivary Gland Neoplasm of Uncertain Malignant Potential” (SUMP) category as defined by the Milan System.
  • - Researchers analyzed FNA cases from three academic institutions to determine the risk of neoplasm (RON) and risk of malignancy (ROM) in different SUMP subtypes, finding that overall ROM for SUMP was 20.8%, with clear cell subtype having a high malignancy rate.
  • - Results showed variability in ROM across institutions and SUMP subtypes, reinforcing the necessity for precise categorization of SUMP lesions, particularly clear cell types, for effective
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Objective: To compare the functional (obstruction relieving) outcomes and complications of unilateral J-cut division, partial and subtotal vaginal removal techniques were performed for mesh-related urethral obstruction (MRUO) in females.

Methods: Patient review included demographics, a medical history and proforma with details of lower urinary tract symptoms (LUTS), physical and urodynamic findings, detailed surgical reports and follow-up data. Variables were compared between the three groups.

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Article Synopsis
  • The RECOVER-Pathology study focuses on analyzing the long-term effects of SARS-CoV-2 (long COVID) by examining postmortem tissue to better understand the prevalence and types of organ injuries related to PASC.
  • The study will involve detailed autopsies of individuals who died at least 15 days after their initial COVID-19 infection, with the aim of linking pathological findings to clinical characteristics and identifying potential causes of ongoing symptoms.
  • As the largest autopsy study on long COVID in the U.S., RECOVER-Pathology seeks to contribute significantly to knowledge about the mechanisms behind organ damage and to help guide future treatments.
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Herein, we aimed to describe the outcomes of patients with blood stream infections due to carbapenem-resistant Klebsiella pneumoniae (CR-Kp) who received ertapenem plus meropenem combination treatment (EMCT). A total of 53 patients with culture proven CR-Kp bacteremia treated with ertapenem + meropenem were included. The patients with secondary bacteremia due to urinary tract infection exhibited a significantly lower 1-month mortality (OMM), particularly in those with microbiological eradication and those with end-of-treatment success.

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Article Synopsis
  • The 2019 guidelines recommend women with an unsatisfactory Pap test and negative HPV test undergo repeat screening in 2 to 4 months, as a negative HPV result may not be definitive due to potential sample issues.* -
  • Our study analyzed data from 1,496 cases with unsatisfactory Pap tests and HPV cotests, finding that a negative HPV test was very predictive of the absence of high-grade lesions.* -
  • Despite a low compliance rate for follow-up screenings (45.1%), the results suggest that women with an unsatisfactory Pap test and negative HPV results may not need to return for repeat testing as soon as previously recommended.*
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Objective: Wound dehiscence is associated with high morbidity and mortality. This study aimed to analyze the risk factors and comorbidities in the patients undergoing radical cystectomy with early postoperative wound dehiscence.

Methods: In all, 539 patients with bladder cancer who underwent radical cystectomy and urinary diversion at a single center between January 2008 and January 2022 were included in the study.

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Objective: The present study aimed to evaluate the predictive value of bony pelvic parameters measured by computerized tomography (CT) for use in the estimation of the likely technical difficulties that may be encountered when performing open radical prostatectomy (RP) for localized prostate cancer.

Material And Methods: One hundred patients, undergoing open RP for localized prostate cancer, were evaluated between October 2016 to November 2018. All operations were performed by the same experienced surgeon.

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  • The study investigates outcomes of Pap tests with atypical glandular cells (AGCs) and concurrent squamous cell abnormalities (AGC + Sq) compared to AGCs without squamous cell abnormalities (AGC-alone).
  • Data from 287 Pap tests indicated that 55% of AGC + Sq cases tested positive for high-risk human papillomavirus (HR-HPV), in contrast to just 14% in AGC-alone cases, suggesting AGC + Sq is associated with a higher likelihood of significant lesions.
  • The findings highlight that while HR-HPV testing and age provide valuable insights, relying solely on HR-HPV to triage patients could lead to overlooking important lesions, especially in AGC + Sq cases
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Clonorchis sinensis, a liver fluke parasite, infects humans through ingestion of raw or undercooked fish, crabs, or crayfish in endemic areas where the parasite is found. Clonorchis sinensis infects the liver, gallbladder, and bile duct in humans, causing Clonorichiasis. Although the majority of patients are asymptomatic, long-lasting infections may cause severe disease.

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Aim: The presence of intraductal carcinoma of the prostate (IDC-P) in radical prostatectomy (RP) specimens correlates with adverse prognostic factors such as worse biochemical recurrence-free survival, higher grade and stage disease. This study aimed to investigate the effect of IDC-P in radical prostatectomy specimens on short-term oncological outcomes.

Materials And Methods: Patients who underwent RP at our clinic for prostate cancer between May 2016 and November 2019 were included in the study.

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Article Synopsis
  • The study evaluates the effectiveness of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) compared to the original cytology classification for diagnosing salivary tumors.
  • It analyzes the diagnostic performance metrics (sensitivity, specificity, etc.) of both systems using data from 101 resected tumors, finding that MSRSGC has slight advantages in some areas.
  • Interobserver agreement was high with MSRSGC, indicating that different cytopathologists are likely to come to similar conclusions when using this system.
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Objective: Postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) plays an important role in the management of advanced germ cell testicular tumors. Bilateral template lymph node dissection is considered a standard treatment in postchemotherapy residual masses; however, modified unilateral templates have gained acceptance in patients with unilateral residual disease. In this study, we aimed to demonstrate the perioperative and oncological outcomes of the patients with advanced testicular cancer who underwent unilateral modified template PC-RPLND in our center.

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Myoepithelial carcinoma (MEC) of soft tissue, also known as malignant myoepithelial tumor, is an uncommon malignancy. Cytologic diagnosis of this entity is challenging due to its rarity and heterogeneous morphology. We report a case of MEC in a 22-year-old man, who presented with a 6.

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Article Synopsis
  • The study investigates the correlation between ACR TI-RADS ultrasound scores and the risk of malignancy in cases with indeterminate thyroid fine needle aspiration cytology.
  • A total of 46 cases were analyzed, revealing that most indeterminate cases had higher TI-RADS scores (TR4 and TR5) and that RAS mutations were the most common molecular alteration identified.
  • The results suggest that while molecular testing is useful for TR4 and TR5 lesions, lower TI-RADS scores (TR2 and TR3) frequently showed no significant molecular changes, indicating the importance of ultrasound features in evaluating indeterminate cytology.
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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for coronavirus disease 2019 (COVID-19), is known to cause severe respiratory infections with occasional accompanying pleural effusion (PE), pericardial effusion (PCE), or peritoneal effusion (PTE). The effect of COVID-19 on effusion cytology is not yet known. This study aimed to examine the cytomorphologic features and workup of effusion fluids in patients with active COVID-19 infection versus those in recovery.

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Article Synopsis
  • The study investigates p16 immunohistochemistry (IHC) in cytology cell blocks from fine-needle aspiration samples of head and neck squamous cell carcinoma, comparing it to surgical pathology results to assess reproducibility.
  • Using 40 samples, five cytopathologists independently scored p16 IHC staining, establishing performance metrics such as sensitivity, specificity, and inter-rater reliability (Gwet's coefficient).
  • Findings indicate that a positivity threshold of greater than 10% achieves 100% specificity with varying sensitivity, suggesting that this threshold may be suitable for interpreting p16 IHC in cytology compared to surgical pathology standards.
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Aim: We aimed to compare the functional results of two different vesicourethral anastomosis (VUA) techniques used in open retropubic radical prostatectomy.

Methods: A total of 476 patients including the first group with four-focus VUA at 12-, 3-, 6-, and 9-o'clock positions (n = 288) and the second group with six-focus VUA at 12-, 2-, 4-, 6-, 8-, and 10-o'clock (n = 188) were included in the study. Perioperative data, erectile function, and continence status over a 12-month period were compared.

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Introduction And Aim: Ureteroenteric anastomosis stricture (UEAS) is one of the complications of urinary diversion and may lead to serious consequences. In this study, we evaluated our UEAS revision technique outcomes performed with a low lombotomy incision in the lateral decubitus position.

Materials And Methods: Eleven patients who underwent surgical repair due to isolated right UEAS between January 2010 and June 2019 were included in the study.

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Many state-wide, city-wide, and hospital-wide changes have been implemented due to the ongoing COVID-19 crisis. We describe lessons learned in an anatomic pathology division at a tertiary care center during the peak of the COVID-19 pandemic in the hopes that knowledge of our experiences can benefit other pathology departments as they encounter this pandemic. Five categories that are critical in strategic planning for the COVID-19 pandemic are discussed: workload, departmental policy revisions, impact on faculty, workforce staffing, and impact on educational programs, including residency and fellowship training.

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Objective: In this study, we aimed to make a comprehensive comparison of the first hundred robot-assisted radical prostatectomy (RARP) and open retropubic radical prostatectomy (RRP) cases of a single surgeon in a high-volume center.

Methods: Preoperative, perioperative and postoperative data were collected retrospectively. Perioperative, oncological data and functional results in the first year were compared between the two groups.

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Endometriosis can affect 10-15% of the women in their reproductive age and it is characterized with the presence of the functional endometrium tissue outside the uterine cavity. Up to 10% of the cases with urinary system endometriosis may involve the ureter. Left distal ureter is the most common site of involvement.

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Purpose: We aimed to investigate the histopathological correlation of the suspected prostate malignancy detected in multiparametric prostate magnetic resonance imaging (mpMRI).

Materials And Methods: The data of 93 patients underwent radical prostatectomy and had preoperative mpMRI were examined. Age and pre-operative Prostate-Specific Antigen value were retrospectively collected from patient files.

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