A Phase 3, 28-week, multicentre, randomised, double-blind, placebo-controlled trial (OA-10) to evaluate the efficacy and safety of a single injection of lorecivivint in the target knee joint of moderately to severely symptomatic osteoarthritis patients.

Objectives: To assess the efficacy and safety of an intra-articular (IA) CLK/DYRK inhibitor, lorecivivint (LOR), for the treatment of moderate to severe symptomatic knee osteoarthritis (OA).

Methods: This was a Phase 3, 28-week, multicentre, double-blind, placebo-controlled study evaluating the efficacy and safety of a single IA injection of LOR. Patients with ACR-defined knee OA, Kellgren-Lawrence (KL) grades 2-3, and pain Numeric Rating Scale (NRS) ≥4 and ≤8 in the target knee were randomised (1:1) to receive LOR 0.

Phase 3, 56-week, randomised, double-blind, placebo-controlled study utilising patient-reported and radiographic outcomes evaluating the efficacy and safety of a lorecivivint injection in patients with moderate to severe knee osteoarthritis: OA-11 Study.

Objectives: To determine the efficacy, safety, and tolerability of intraarticular (IA) lorecivivint (LOR) in the treatment of knee osteoarthritis (OA).

Methods: Patients with American College of Rheumatology criteria-defined knee OA, Kellgren-Lawrence (KL) grades 2-3, and medial Joint Space Width (JSW) by radiograph between 1.5 and 4 mm in the target knee were enrolled in this phase 3, 56-week, multicentre, double-blind, placebo-controlled study.

Evaluation of Safety and Efficacy of a Single Lorecivivint Injection in Patients with Knee Osteoarthritis: A Multicenter, Observational Extension Trial.

Introduction: Lorecivivint (LOR), a CDC-like kinase/dual-specificity tyrosine kinase (CLK/DYRK) inhibitor thought to modulate inflammatory and Wnt pathways, is being developed as a potential intra-articular knee osteoarthritis (OA) treatment. The objective of this trial was to evaluate long-term safety of LOR within an observational extension of two phase 2 trials.

Methods: This 60-month, observational extension study (NCT02951026) of a 12-month phase 2a trial (NCT02536833) and 6-month phase 2b trial (NCT03122860) was administratively closed after 36 months as data inferences became limited.

Fate and effect of Polyamide-6 microplastics in mesophilic and thermophilic anaerobic digestion.

Research has demonstrated that depending on the type and concentration, microplastics affect anaerobic digestion (AD). Owing to the high abundance of polyamide-6 (PA6) in wastewater treatment plants and limited understanding of its behavior, this study investigates PA6 microplastics' effect in AD. Biochemical methane potential experiments were performed under mesophilic (35 °C) and thermophilic (55 °C) conditions using PA6 at concentrations from 0 to 200 particles/g total solids (TS).

Evaluation of the relationship between mast cell activation and postural orthostatic tachycardia syndrome in children and adolescents.

Objective: Postural orthostatic tachycardia syndrome (POTS) is one of the orthostatic intolerance syndromes that are common in young adolescents and impair quality of life. POTS is a multi-systemic disease. Many mechanisms have been defined in POTS etiology, such as autonomic denervation, hypovolemia, hyperadrenergic stimulation, low condition, and hypervigilance.

Transcriptomic evaluation of metals detected in placenta.

This research aims to assess the concentration of metals in human and canine placentas from the same geographic area and to investigate how these metal levels influence gene expression within the placenta. Placentas of 25 dogs and 60 women who had recently given birth residing in Ankara, Turkey were collected and subjected to metal analysis using ICP-OES. Placentas with detectable metal levels underwent further examination including Next Generation Sequencing, transcriptional analysis, single nucleotide polymorphism investigation, and extensive scrutiny across various groups.

Surface defects due to bacterial residue on shrimp shell.

The changes in the surface chemistry and morphological structure of chitin forms obtained from shrimp shells (ShpS) with and without microorganisms were evaluated. Total mesophilic aerobic bacteria (TMAB), estimated Pseudomonas spp. and Enterococcus spp.

Selective adsorption of single and binary dyestuffs by citrus peel: Characterization, and adsorption performance.

The powdered citrus peel, which has been replaced with sodium hydroxide, was used in this study to test how well methylene blue and reactive black 5 dyestuff absorbed one or both. To find out about the texture and surface chemistry of modified citrus peel, Fourier transform infrared spectroscopy and scanning electron microscope analyses were carried out. Fourier transform infrared spectroscopy data revealed the presence of amphoteric radicals on the modified citrus peel surface, indicating the effective adsorption of methylene blue and reactive black 5.

Safety, Tolerability, and Pharmacokinetics of Same-Knee Intra-Articular Injection of Corticosteroid and Lorecivivint Within 7 Days: An Open-Label, Randomized, Parallel-Arm Study.

Introduction: Knee osteoarthritis (OA) is a common painful disorder. Intra-articular (IA) corticosteroid injections are frequently prescribed to treat knee pain. Lorecivivint (LOR), a novel IA cdc2-Like Kinase (CLK)/Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase (DYRK) inhibitor thought to modulate Wnt and inflammatory pathways, has appeared safe and demonstrated improved patient-reported outcomes compared with placebo.

Use of different food wastes as green biosorbent: isotherm, kinetic, and thermodynamic studies of Pb.

Lead (Pb) can contaminate waters from many sources, especially industrial activities. This heavy metal is an amphoteric, toxic, endocrine-disrupting, bioaccumulative, and carcinogenic pollutant. One of the effective and economical processes used to remove lead from water is adsorption.

Effect of dual tasking on postural control in individuals with schizophrenia.

Objective: To investigate the effect of dual tasking on postural control in individuals with schizophrenia.

Methods: Fifteen outpatients with schizophrenia and 15 healthy controls were included. Postural control was assessed with postural sway velocity (PSV) using Balance Master System during three different tasks: single task (standing on a force platform), cognitive task (categorical verbal fluency) and motor task (holding a cup of water) in four conditions: on firm surface with eyes open (1) and closed (2), on foam surface with eyes open (3) and closed (4).

Balance Control and Plantar Pressure Distribution in Hyperkyphotic Adolescent and Young Adults.

Aim: To assess differences in static/dynamic balance and plantar pressure distribution (PPD) in hyperkyphotic adolescents and young adults based on sagittal spinopelvic alignment changes.

Material And Methods: Twelve hyperkyphotic patients and 12 normal subjects were included in the study group and control group, respectively. Lateral spine X-rays were used to evaluate spinopelvic parameters, thoracic kyphosis, lumbar lordosis (LL), and sagittal vertical axis offsets.

Investigation of monthly residues of polycyclic aromatic hydrocarbons in water and sediment samples from Kirikkale Kizilirmak River Basin.

Polycyclic aromatic hydrocarbons (PAHs) contain two or more benzene rings and are categorized as general environmentally harmful pollutants. PAHs occur because of various combustion and pyrolysis processes with different environmental and anthropogenic sources. The Kizilirmak River is one of the major important water sources used for drinking water and irrigation purposes in Turkey.

Prospective evaluation of tolerance to unheated milk-boiled egg after baked milk-egg tolerance under 2 years.

Background: The time to acquisition of tolerance to unheated milk and regular egg after achievement of tolerance to baked goods is not known.

Objective: To determine the time to acquisition of unheated-milk-regular-egg tolerance, after the tolerance of the baked forms, in children younger than 2 years.

Methods: An initial oral food challenge with baked milk (BM) and baked egg (BE) was performed on patients who were reactive to unheated milk-regular egg, respectively.

Investigation of the Relationships Among Clinical Measures of Foot Posture in Individuals with and Without Pronated Foot.

Background: Many indirect clinical techniques have been developed to assess foot posture; however, there is relatively little research investigating the relationships among these techniques. We investigated the relationships among the most commonly used clinical measures of foot posture-Foot Posture Index-6 (FPI-6), navicular drop (NDP), navicular drift (NDT), and static and dynamic arch indices (SAI and DAI)-in individuals with normal foot posture and those with pronated foot.

Methods: Sixty-three individuals with FPI-6 scores of 0 to 12 were included.

Comparing Patient-Reported Outcomes From Sham and Saline-Based Placebo Injections for Knee Osteoarthritis: Data From a Randomized Clinical Trial of Lorecivivint.

Background: Durable, meaningful symptom responses to intra-articular saline placebo injections are observed in knee osteoarthritis (OA) trials, but it is unclear if these are due to physiological effects.

Purpose: To perform a prospective comparison of patient-reported outcome responses among participants with knee OA who underwent intra-articular injection of saline-based placebo or sham (dry needle).

Study Design: Randomized controlled trial; Level of evidence, 2.

Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg).

Background & Aims: After a first Helicobacter pylori eradication attempt, approximately 20% of patients will remain infected. The aim of the current study was to assess the effectiveness and safety of second-line empiric treatment in Europe.

Methods: This international, multicenter, prospective, non-interventional registry aimed to evaluate the decisions and outcomes of H pylori management by European gastroenterologists.

A Prospective Assessment of Clinical Characteristics and Responses to Dietary Elimination in Food Protein-Induced Allergic Proctocolitis.

Background: Some aspects of diagnostic elimination/challenge diets in food protein-induced allergic proctocolitis (FPIAP) are still poorly defined.

Objective: This study investigated the symptom spectrum, time required for resolution of each symptom, triggering foods, and risk factors for multiple food allergies (MFA) in FPIAP.

Methods: Infants referred with visible blood in stool were enrolled after etiologies other than FPIAP had been excluded.

Investigation of the perceptual and cognitive asymmetry in the auditory system in patients with adolescent idiopathic scoliosis.

Background: Studies have shown that perceptual and cognitive asymmetries are present in the auditory system in patients with adolescent idiopathic scoliosis (AIS). The Dichotic Listening (DL) paradigm was formerly performed in non-forced (NF) conditions only, and no study has examined the conditions of attention to one ear.

Objective: To investigate the perceptual and cognitive asymmetry in the auditory system in patients with AIS as well as the asymmetry changes according to the curvature characteristics of patients with AIS.

Food-induced anaphylaxis in early childhood and factors associated with its severity.

Several factors that increase the risk of severe food-induced anaphylaxis have been identified. We aimed to determine the demographic, etiologic, and clinical features of food-induced anaphylaxis in early childhood and also any other factors associated with severe anaphylaxis. We carried out a medical chart review of anaphylaxis cases from 16 pediatric allergy and immunology centers in Turkey.

Are large local reactions a marker for systemic reactions to subcutaneous immunotherapy in children?

Background: Previous studies involving predominantly adults concluded that the patients developing frequent large local reactions (LLRs) might be at greater risk for systemic reactions (SRs) during subcutaneous allergen immunotherapy (SCIT).

Objective: To determine the rate of side effects to SCIT and evaluate frequency of LLR among pediatric patients with SRs.

Methods: The retrospective study included pediatric patients receiving SCIT.

Unacceptable Antibiotic Resistance Rates for Helicobacter pylori in Turkey: Something Must Change.

Background: It is known that clarithromycin resistance has increased over the years (success rate 60%). The aim of the study was to investigate the importance of regional antimicrobial resistance rates for full accuracy of both diagnosis and treatment of Helicobacter pylori infection.

Methods: This study was carried out in the University Hospital Department of Gastroenterology.