Publications by authors named "Simran Rai"
Article Synopsis
- - Human threadworm is a globally distributed parasite affecting over 600 million people, with serious implications for immunosuppressed individuals, yet its prevalence among Fijian migrants in the UK is largely unknown.
- - A study involving 250 Fijian migrants in the UK revealed a significant rate of gastrointestinal parasites (GIPs), with 35.1% testing positive for threadworm and 6.8% for hookworms, based on comprehensive diagnostic methods.
- - Findings emphasized the need for specialized parasitological testing, particularly multiplex real-time PCR (rtPCR), which proved more effective than traditional microscopy in diagnosing infections among chronic cases in this population.
Tyrosyl-tRNA synthetase ligates tyrosine to its cognate tRNA in the cytoplasm, but it can also be secreted through a noncanonical pathway. We found that extracellular tyrosyl-tRNA synthetase (YRS) exhibited proinflammatory activities. In addition to acting as a monocyte/macrophage chemoattractant, YRS initiated signaling through Toll-like receptor 2 (TLR2) resulting in NF-κB activation and release of tumor necrosis factor α (TNFα) and multiple chemokines, including MIP-1α/β, CXCL8 (IL8), and CXCL1 (KC) from THP1 monocyte and peripheral blood mononuclear cell-derived macrophages.
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