Publications by authors named "Simran Handa"
Article Synopsis
- Epstein-Barr virus (EBV) is linked to serious health issues, including cancer, infectious mononucleosis, multiple sclerosis, and rheumatoid arthritis, leading to 165,000 deaths annually.
- An effective vaccine is needed to target both epithelial and B cells during oral transmission of EBV, with gH/gL glycoprotein complex showing promise as a candidate.
- Research indicates that nanoparticle vaccines containing multiple copies of gH/gL provide significantly better immunogenicity than monomeric versions, successfully eliciting protective antibodies in experimental models.
ABC transporters couple ATP hydrolysis to the transport of substrates across cellular membranes. This protein superfamily has diverse activities resulting from differences in their cargo and subcellular localization. Our work investigates the role of the ABCG family member WHT-2 in the biogenesis of gut granules, a lysosome-related organelle.
View Article and Find Full Text PDFTumor-derived extracellular vesicles (TEV) "educate" healthy cells to promote metastases. We found that melanoma TEV downregulated type I interferon (IFN) receptor and expression of IFN-inducible cholesterol 25-hydroxylase (CH25H). CH25H produces 25-hydroxycholesterol, which inhibited TEV uptake.
View Article and Find Full Text PDFCell type-specific modifications of conventional endosomal trafficking pathways lead to the formation of lysosome-related organelles (LROs). C. elegans gut granules are intestinally restricted LROs that coexist with conventional degradative lysosomes.
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