Prison cell spatial density and infectious and communicable diseases: a systematic review.

Objective: To summarise the extent and quality of evidence on the association between prison cell spatial density (a measure of crowding) and infectious and communicable diseases transmission among prisoners.

Design: Systematic review.

Data Sources: Embase, PubMed, Medline, Scopus, Web of Science, PsycINFO, PsycExtra, ProQuest Databases, ProQuest Dissertations and Theses Global, Index to Legal Periodicals, InformitOnline, Cochrane Library, Criminal Justice Abstracts and ICONDA were searched to 31 December 2018.

Antibiotic modulation of mucins in otitis media; should this change our approach to watchful waiting?

Background: Gel-forming mucins (GFMs) play important roles in otitis media (OM) pathogenesis. Increased mucin expression is activated by pathogens and proinflammatory cytokines. Bacterial biofilms influence inflammation and resolution of OM and may contribute to prolonged mucin production.

LobSig is a multigene predictor of outcome in invasive lobular carcinoma.

Invasive lobular carcinoma (ILC) is the most common special type of breast cancer, and is characterized by functional loss of E-cadherin, resulting in cellular adhesion defects. ILC typically present as estrogen receptor positive, grade 2 breast cancers, with a good short-term prognosis. Several large-scale molecular profiling studies have now dissected the unique genomics of ILC.

A Prospective Study of Parent Health-Related Quality of Life before and after Discharge from the Neonatal Intensive Care Unit.

Objective: To determine how infant illness and parent demographics are associated with parent health-related quality of life (HRQL) during and 3 months after hospitalization in the neonatal intensive care unit (NICU). We hypothesized that parents of extremely preterm infants would report lower NICU HRQL than other parents, and that all parents would report improved HRQL after discharge.

Study Design: This prospective study of parent-infant dyads admitted to a level IV NICU for ≥14 days from 2016 to 2017 measured parent HRQL before and 3 months after discharge using the Pediatric Quality of Life Inventory Family Impact Module.

Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease.

Background & Aims: The intestinal microbiome might affect the development and severity of nonalcoholic fatty liver disease (NAFLD). We analyzed microbiomes of children with and without NAFLD.

Methods: We performed a prospective, observational, cross-sectional study of 87 children (age range, 8-17 years) with biopsy-proven NAFLD and 37 children with obesity without NAFLD (controls).

Comparing the outcomes of isolated, serious traumatic brain injury in older adults managed at major trauma centres and neurosurgical services: A registry-based cohort study.

Background: The incidence of older adult traumatic brain injury (TBI) is increasing in both high and middle to low-income countries. It is unknown whether older adults with isolated, serious TBI can be safely managed outside of major trauma centres. This registry based cohort study aimed to compare mortality and functional outcomes of older adults with isolated, serious TBI who were managed at specialised Major Trauma Services (MTS) and Metropolitan Neurosurgical Services (MNS).

Developing Attributes and Attribute-Levels for a Discrete-Choice Experiment: An Example for Interventions of Impulsive Violent Offenders.

Background: Discrete-Choice Experiments (DCEs) are used to assess the strength of preferences and value of interventions, but researchers using the method have been criticised for failing to either undertake or publish the rigorous research for selecting the necessary attributes and levels. The aim of this study was to elicit attributes to inform a DCE to assess societal and offenders' preferences for, and value of, treatment of impulsive-violent offenders. In doing so, this paper thoroughly describes the process and methods used in developing the DCE attributes and levels.

A comparison of impulse response modification techniques for time reversal with application to crack detection.

Time reversal (TR) focusing used for nonlinear detection of cracks relies on the ability of the TR process to provide spatially localized, high-amplitude excitation. The high amplitude improves the ability to detect nonlinear features that are a signature of the motion of closed cracks. It follows that a higher peak focal amplitude than what can be generated with the traditional TR process will improve the detection capability.

Agreement between medical record and administrative coding of common comorbidities in orthopaedic trauma patients.

Objective: To i) quantify the agreement between comorbidities documented within medical records and an orthopaedic trauma dataset; and ii) compare agreement between these sources before and after the introduction of new comorbidity coding rules in Australian hospitals.

Study Design And Setting: A random sample of adult (≥ 16 years) orthopaedic trauma patients (n = 400) were extracted from the Victorian Orthopaedic Trauma Outcomes Registry (VOTOR). Diagnoses of obesity, arthritis, diabetes and cardiac conditions documented within patients' medical records were compared to ICD-10-AM comorbidity codes (provided by hospitals) for the same admission.

Chronic pain in adults with sickle cell disease is associated with alterations in functional connectivity of the brain.

Chronic pain affects 50% of adults with sickle cell disease (SCD). Although central sensitization is thought to contribute to the pathogenesis of this chronic pain, no studies have examined differences in functional connectivity of the brain between patients with SCD with and without chronic pain. We performed an observational cohort study using resting-state functional MRI (rsfMRI) of the brain on adults with SCD with and without chronic pain.

Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers.

Background: Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of the somatic mutation burden of tumours. Here, we investigated the utility of tumour and matched germline WGS for understanding aetiology and treatment opportunities for high-risk individuals with familial breast cancer.

Patients And Methods: We carried out WGS on 78 paired germline and tumour DNA samples from individuals carrying pathogenic variants in BRCA1 (n = 26) or BRCA2 (n = 22) or from non-carriers (non-BRCA1/2; n = 30).

Adolescent Inpatients With Eating Disorders: Comparison Between Acute and Chronic Malnutrition States on a Refeeding Protocol.

This study is a comparison of eating disorder patient outcomes on similar nutrition regimens regardless of degree of malnutrition. Acuity of symptoms in chronically and acutely malnourished patients were analyzed to determine the influence the duration of malnutrition has on refeeding syndrome. Patient outcomes did not differ based on chronicity of malnutrition and are compatible with previous studies in terms of weight gain, medical stabilization, and rate of electrolyte imbalance.

Impact of comorbidity on health outcome after a transport-related injury.

Introduction: Understanding the impact of comorbidity on health outcomes is important given that comorbidities can affect survival, morbidity, service delivery costs and healthcare utilisation. However, little is known about the types of comorbidities affecting specific health outcomes after minor to moderate road trauma.

Methods: This study involved 1574 participants who claimed injury compensation following transport-related injury.

Oncological safety of laparoscopic versus open colorectal cancer surgery in obesity: a systematic review and meta-analysis.

Background: Colorectal cancer resection in the obese (OB) patients can be technically challenging. With the increasing adoption of laparoscopic surgery, the benefits remain uncertain. Hence, the aim of this study is to assess the short- and long-term outcomes of laparoscopic compared to open colorectal cancer resection in the OB patients.

Process-dependent mechanical and optical properties of nanostructured silicon carbonitride thin films.

Amorphous hydrogenated silicon carbonitride (a-SiCN:H) thin films were grown using electron cyclotron resonance chemical vapour deposition using a mixture of methane, nitrogen, and silane as precursors. The origin of the variation of macroscopic properties such as hardness (H), elastic modulus (E), photoluminescence (PL), and the optical band gap was investigated through their correlation with the microscopic features of a-SiCN:H thin films as a function of the process parameters, including the deposition temperature and methane gas flow rate. From a microstructural perspective, the thin films were investigated using x-ray photoelectron spectroscopy, Rutherford backscattering spectrometry, elastic recoil detection, transmission electron microscopy, and x-ray diffraction.

Longitudinal changes in the gut microbiome of infants on total parenteral nutrition.

Background: Animal studies suggest that total parenteral nutrition (TPN) may alter bacterial colonization of the intestinal tract and contribute to complications. Progressive changes in gut microbiome of infants receiving TPN are not well understood.

Methods: Infants with and without TPN/soy lipid were enrolled in a prospective, longitudinal study.

Nausea exacerbates symptom burden, quality of life, and functioning in adolescents with functional abdominal pain disorders.

Background: Nausea frequently co-exists with functional abdominal pain disorders (FAPDs) and may be linked to a higher disease burden. This study aimed to prospectively compare multisystem symptoms, quality of life, and functioning in FAPDs with and without nausea.

Methods: Adolescents ages 11-18 years fulfilling Rome III criteria for a FAPD were grouped by the presence or absence of chronic nausea.

It's time to recognise self care as an integral component of health systems.

Empowering and supporting people to manage their own health benefits everyone

Cardiovagal modulation in pediatric functional gastrointestinal disorders.

Background And Objectives: Though reduced cardiovagal modulation accompanies adult IBS, adolescents with functional gastrointestinal disorders (FGID) have not been studied. We aim to investigate whether adolescents with FGID have reduced cardiovagal modulation.

Methods: After 10-minute supine rest, we recorded ECG for 5-minute supine and 5-minute standing without support in healthy and FGID-affected adolescents.

Risk of hypotensive reactions is increased when using partial saline replacement for therapeutic plasma exchange.

Background: Partial normal saline replacement during plasma exchange procedures is a common practice to reduce procedure costs but may increase the risk of adverse events, such as hypotension and citrate reactions. The goal of this study was to compare adverse event rates for the patients that used albumin or albumin/saline as replacement.

Study Design And Methods: A retrospective chart review was done of plasma exchange procedures that used all albumin or 80% albumin to 20% normal saline (80/20) as replacement.

Organ-on-a-chip technology: turning its potential for clinical benefit into reality.

Organs-on-a-chip (OOAC) are research platforms containing cellular models designed to recapitulate relevant biological cues and, in some cases, enable communication between 'on-chip' connected organs. With enhanced physiological relevance, improvements in predictivity of the efficacy and toxicity of test compounds are anticipated. However, there are challenges to demonstrate the 'gain of confidence' of this technology for patient benefit.

Cystic Fibrosis Plasma Blunts the Immune Response to Bacterial Infection.

Cystic fibrosis (CF) is caused by mutations of the gene encoding the CF transmembrane conductance regulator. It remains unclear whether the abnormal immune response in CF involves extrinsic signals released from the external or internal environment. We sought to characterize the peripheral immune signatures in CF and its association with clinical phenotypes.

Reflexivity denied? The emotional and health-seeking resources of men facing disadvantage.

Based on focus group discussions of self-generated photographs of individuals aged 19-67 resident in urban Northwest England, this article examines the health narratives of men facing disadvantage because of economic hardship and/or mental health difficulty (mhd). In contrast to stereotypes of men as uncomfortable with emotions linked to vulnerability, we explore how such men can develop within self-help groups the kind of emotional resources that encourage health-seeking behaviours. Our argument contrasts with theories that risk denying/diminishing working-class men's emotional reflexivity or that frame reflexivity (thought on feelings and behaviour to effect life changes) as individualised and more available to middle-class (younger) men.