Bioactivity of fractions and constituents of Piper capense fruits towards a broad panel of cancer cells.

Ethnopharmacological Relevance: Piper capense is a medicinal spice whose fruits are traditionally used as aqueous decoction to heal several ailments such as trypanosomiasis, helminthic infections, and cancer.

Aim Of The Study: (1) To perform phytochemical investigation of the methanol extract of Piper capense; (2) to evaluate the cytotoxicity of botanicals (PCF, fractions PCFa-e), isolated phytochemicals on a broad panel of animal and human cancer cell lines; (3) to evaluate the induction of apoptosis of the most active samples.

Material And Methods: Resazurin reduction assay (RRA) was used to determine the cytotoxicity of the studied samples.

Cytotoxic Constituents of the Bark of towards Multidrug-Resistant Cancer Cells.

The global cancer burden remains a serious concern with the alarming incidence of one in eight men and one in eleven women dying in developing countries. This situation is aggravated by the multidrug resistance (MDR) of cancer cells that hampers chemotherapy. In this study, the cytotoxicity of the methanol extract (HRB), fractions (HRBa, HRBb, and HRBa1-5), and compounds from the bark of (HRB) was evaluated towards a panel of 9 cancer cell lines.

A new polyketide from the bark of Schimp. (Hypericaceae).

The isolation and spectroscopic data of a hitherto undescribed polyketide () from Schimp. (Hypericaceae) together with six known compounds (-) is herein reported. The structure elucidation is based on extensive 1D- and 2D-NMR, infrared, UV and MS experiments.