Self-reported sleep disturbance and inappropriate z-hypnotic use among older adults in general practice.

Background: Sleep disorders such as insomnia may occur in old age, potentially leading to z-hypnotic use. However, few studies have explored older adults' self-reported sleep concerns in relation to z-hypnotic use. We aim to examine this relationship.

Lignin Molar Mass Estimation by Dispersion Analysis.

Lignin's complex and heterogeneous molecular structure poses significant challenges for accurate molar mass determination, which is important for its utilization in industrial applications, such as biochemicals, nanoparticles, biobased binders, and biofuels. This study evaluates the potential of Taylor Dispersion Analysis (TDA) for measuring lignin size and compares it with size-exclusion chromatography (SEC) and diffusion-ordered spectroscopy (DOSY) NMR. Using dual Gaussian fitting, flow-induced dispersion analysis (FIDA), a TDA-based method, successfully determined the average hydrodynamic radii of multiple species in solvent-fractionated soda grass lignin samples, producing results consistent with DOSY.

Characterization and structural analysis of alcohol-fractionated lignin biofuels processed at ambient temperature.

This study introduces Cold-processed Lignin in (M)ethanol Oil (CLEO/CLiMO), a novel biofuel technology derived from the alcohol-fractionation of lignin at ambient temperatures, offering a sustainable alternative to conventional marine fuels. The production process achieved solid loadings of up to 60 wt% lignin and a volumetric energy density 39 % higher than pure alcohols. Lignin concentrations above 30 wt% promoted colloidal stability through the proposed formation of a spanning network of lignin aggregates, associated with a 100-fold increase of viscosity.

Improving the production efficiency and sustainability of lignin-alcohol fuel processed at ambient temperature.

Lignin represents a promising source of renewable energy. The development of CLEO (Cold processed Lignin Ethanol Oil) fuel introduces a novel lignin valorization approach, proposing its potential as maritime biofuel. However, its industrial success depends on enhancing fractionation yields and reducing solvent evaporation, which necessitates a detailed analysis of lignin properties, solvent types, and process parameters.

Moving Beyond Clinical Imaginaries: Technogeographies of the Everyday Urban.

In this paper, we analyse the intersections between care and place in mundane spaces not explicitly designed for the provision of care, and where digital technologies are used to mediate ecologies of distress in the city. We locate our analysis alongside studies of how digital technologies impact the experience of care within non-clinical spaces, whilst noting that much research on the use of technologies for care remains haunted by clinical imaginaries. Bringing together ideas of multi-sited therapeutic assemblages, technogeographies of care, and how places-by-proxy can act as conduits for care, we explore an example of an online app being used in public space to manage experiences of anxiety in an everyday urban environment.

An effective method for preparing histological sections of blow fly intra-puparial stages for minimum PMI estimations.

Blow flies (Diptera: Calliphoridae) are generally early colonisers of fresh cadavers, enabling the estimation of a minimum post-mortem interval (PMI) based on an accurate aging of the oldest immature stages associated with a cadaver. In blow flies, the pupal stage and the subsequent development of the adult take place inside a protective case, the puparium, formed from the hardened and darkened cuticle of the third instar larva. Because the puparium is an opaque structure that shows virtually no external changes, qualitative analyses of the internal tissues can be very informative for determining reliable age-specific morphological markers.

Stolleagrion foghnielseni (Odonata, Cephalozygoptera, Dysagrionidae) gen. et sp. nov.: a new odonatan from the PETM recovery phase of the earliest Ypresian Fur Formation, Denmark.

We describe the new genus and species Stolleagrion foghnielseni n. gen. et sp.

Mortality and health-related quality of life in older adults with long-term use of opioids, z-hypnotics or benzodiazepines: a prospective observational study at 5 years follow-up.

Objectives: Disease and medication use in older age is a consequence of age-related declining health. Multimorbidity followed by polypharmacy is common. Central nervous system depressing (CNSD) drugs such as opioids, benzodiazepines and z-hypnotics are not recommended for long-term use in older adults but are in use by many.

Brief Intervention as a Method to Reduce Z-Hypnotic Use by Older Adults: Feasibility Case Series.

Background: Z-hypnotics or z-drugs are commonly prescribed for insomnia and sleep difficulties in older adults. These drugs are associated with adverse events and dependence and are not recommended for long-term use. Despite evidence of older adults being more sensitive to a wide array of adverse events and clinical guidelines advocating limiting use, inappropriate use in this population is still prevalent.

Vitality and nature in psychiatric spaces: Challenges and prospects for 'healing architecture' in the design of inpatient mental health environments.

Historically, nature has been considered central to healing and recovery in institutional mental health settings, with inpatient spaces designed to mirror the restorative forces nature may afford. Within contemporary healthcare architecture, the discourse surrounding nature's role has once again become prominent, especially in the concept of 'healing architecture'. While the literature on 'healing architecture' primarily considers how to connect recovery to nature through interventions in the built environment, less interest has been directed towards how nature is configured in design processes and what implications that has for the everyday experiences of patients and staff.

Measuring pain intensity in older adults. Can the visual analogue scale and the numeric rating scale be used interchangeably?

Objectives: Visual analogue scale (VAS) and numeric rating scale (NRS) are two commonly used instruments for measuring pain intensity. Both instruments are validated for use in both clinical and research settings, and share a range of similar aspects. Some studies have shown that the two instruments may be used interchangeably, but the results are conflicting.

Attitudes towards deprescribing in geriatric psychiatry: A survey among older psychiatric outpatients.

Understanding the patient perspective is a significant part of the deprescribing process. This study aimed to explore the attitudes of older patients with psychiatric disorders towards deprescribing. A total of 72 of psychiatric outpatients (68% women; median age 76 years) completed the validated Danish version of the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire.

The damselfly genus Furagrion Petrulevičius et al. (Odonata, Zygoptera) from the early Eocene Fur Formation of Denmark and the dysagrionoid grade.

The earliest Eocene odonate genus Furagrion Petrulevičius et al. from the Danish Fur Formation is revised based on eighteen specimens, two of which apparently have been lost since their publication. The holotype of Phenacolestes jutlandicus Henriksen, type species of Furagrion, is incomplete and lacks the characters currently used to differentiate species, genera and higher taxa in Odonata.

Formation of the Holarctic Fauna: Dated molecular phylogenetic and biogeographic insights from the Quedius-lineage of Ground-Dwelling Rove Beetles (Coleoptera, Staphylinidae).

Although the Holarctic fauna has been explored for centuries, many questions on its formation are still unanswered. For example, i) what was the impact of the uplift of the Himalaya and Tibetan Plateau?, ii) what were the timings and climate of the faunal bridges connecting the Nearctic and Palearctic regions?, and iii) how did insect lineages respond to the late Paleogene global cooling and regional aridification? To answer these, we developed a phylogenetic dataset of 1229 nuclear loci for a total of 222 species of rove beetles (Staphylinidae) with emphasis in the tribe Quediini, especially Quedius-lineage and its subclade Quedius sensu stricto. Using eight fossils for calibrating molecular clock, we estimated divergence times and then analysed in BioGeoBEARS paleodistributions of the most recent common ancestor for each target lineage.

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Rebound pain is a severe post-surgical pain which occurs after the resolution of peripheral nerve blocks. Current literature suggests that rebound pain affects around 50% of those receiving a peripheral nerve block. Possible interventions constitute patient education, bridging analgesia from the resolution of the nerve block, multimodal analgesic regimes, block adjuvants, or continuous pain catheters.

Danowhetaksa gen. nov. with two species from the early Eocene lst Formation from Denmark, the first Palearctic Whetwhetaksidae (Odonata: Cephalozygoptera).

We propose Danowhetaksa n. gen. (Odonata: Whetwhetaksidae) with two new species: D.

Stroke unit demand in Norway - present and future estimates.

Background: All stroke patients should receive timely admission to a stroke unit (SU). Consequently, most patients with suspected strokes - including stroke mimics (SM) are admitted. The aim of this study was to estimate the current total demand for SU bed capacity today and give estimates for future (2020-2040) demand.

Healing Architecture in Healthcare: A Scoping Review.

Objectives: The purpose of this scoping review is to identify evidence on how characteristics of healing architecture in clinical contexts impact clinical practice and patient experiences. Based on these insights, we advance a more practice-based approach to the study of how healing architectures work.

Background: The notion of "healing architecture" has recently emerged in discussions of the spatial organization of healthcare settings, particularly in the Nordic countries.

Impact of introducing capacity-based mental health legislation on the use of community treatment orders in Norway: case registry study.

Background: In 2017, a capacity-based criterion was added to the Norwegian Mental Health Act, stating that those with capacity to consent to treatment cannot be subjected to involuntary care unless there is risk to themselves or others. This was expected to reduce incidence and prevalence rates, and the duration of episodes of involuntary care, in particular regarding community treatment orders (CTOs).

Aims: The aim was to investigate whether the capacity-based criterion had the expected impact on the use of CTOs.

Comparative phylogeography uncovers evolutionary past of Holarctic dragonflies.

Here, we investigate the evolutionary history of five northern dragonfly species to evaluate what role the last glaciation period may have played in their current distributions. We look at the population structure and estimate divergence times for populations of the following species: (Linnaeus), Walker, (Sulzer), Linnaeus and Trybom across their Holarctic range. Our results suggest a common phylogeographic pattern across all species except for .

Intravital microscopy of tumor vessel morphology and function using a standard fluorescence microscope.

Purpose: The purpose of the study was to demonstrate the performance and possible applications of an intravital microscopy assay using a standard fluorescence microscope.

Methods: Melanoma and pancreatic ductal adenocarcinoma xenografts were initiated in dorsal window chambers and subjected to repeated intravital microscopy. The entire tumor vasculature as well as the normal tissue surrounding the tumor was imaged simultaneously with high spatial and temporal resolution.

Attitudes towards deprescribing: The perspectives of geriatric patients and nursing home residents.

Background/objectives: Successful deprescribing requires insight into patients' thoughts about deprescribing. We described attitudes towards deprescribing in a large sample of geriatric patients and nursing home residents.

Design: Interview-based questionnaire study.

Translation, cross-cultural adaptation, and validation of the Danish version of the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire: Version for older people with limited life expectancy.

Background: Knowledge about patients' attitudes towards deprescribing is essential for optimizing medication use. The revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire is a 22-item self-report instrument capturing older patients' beliefs and attitudes towards deprescribing.

Objectives: To translate and cross-culturally adapt the rPATD questionnaire into Danish and subsequently validate it in a cohort of nursing home residents.