A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.

Background: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial.

A latent cardiomyocyte regeneration potential in human heart disease.

Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial.

Re-thinking the online distance instruction based on students' feedback.

During the covid-19 pandemic, schools at all levels were often closed and online distance instruction (ODI) was applied. The main objective of this research was to discover the main didactic features of online distance instruction; and based on the collected data to define didactic recommendations towards improving the quality of the process. Five hypotheses were set that evaluated students' opinions in the areas of teachers' support for learners within ODI, types of sources exploited within ODI, means used for practising and fixing new knowledge within ODI, assessment of learners' performance within ODI, and students' feedback on ODI.

Diploid hepatocytes drive physiological liver renewal in adult humans.

Physiological liver cell replacement is central to maintaining the organ's high metabolic activity, although its characteristics are difficult to study in humans. Using retrospective radiocarbon (C) birth dating of cells, we report that human hepatocytes show continuous and lifelong turnover, allowing the liver to remain a young organ (average age <3 years). Hepatocyte renewal is highly dependent on the ploidy level.

FUCCI-Based Live Imaging Platform Reveals Cell Cycle Dynamics and Identifies Pro-proliferative Compounds in Human iPSC-Derived Cardiomyocytes.

One of the major goals in cardiac regeneration research is to replace lost ventricular tissue with new cardiomyocytes. However, cardiomyocyte proliferation drops to low levels in neonatal hearts and is no longer efficient in compensating for the loss of functional myocardium in heart disease. We generated a human induced pluripotent stem cell (iPSC)-derived cardiomyocyte-specific cell cycle indicator system (TNNT2-FUCCI) to characterize regular and aberrant cardiomyocyte cycle dynamics.

Pupils' Digital Literacy Reflected in Teachers' Attitudes Towards ICT: Case Study of the Czech Republic.

The article deals with the development of digital literacy in primary school learners. Particularly, it focuses on reflection of teacher's type in reaching digital literacy of the primary school pupils. The contribution is considered from the view how (fast) teachers' adopt innovations in this field.

[The analysis of biofilms Vibrio choleraе using technique of transmissive electronic microscopy.].

The cholera continues to be one of the priority problems of world health care that determines necessity of its permanent monitoring and also further investigation of this infection in microbiological and ecological aspects. The phenomenon of biofilm formation plays a significant role among mechanisms permitting comma bacillus year by year to retain its ecological niche and to spread in various basins over a period of decades. The application of techniques of electronic microscopy played a decisive role in studying the process of biofilm formation.

[Assessment of medical care quality in craniocerebral trauma on the base of data analysis].

An analysis of 658 medical records of inpatient treatment from 15 hospitals of St.Petersburg was made using a computer-aided technology of the assessment of medical care quality. It was revealed that a proper quality of medical care in craniocerebral trauma was only in 52.

[The srategy of programed multistage surgical treatment ("damage control surgery") of neurotrauma].

A retrospective analysis of diagnostics and surgical treatment was made in 440 patients with polytrauma, who were on the treatment in hospitals in Saint-Petersburg, Syktyvkar and Omsk during 2009-2012. The neurotrauma was the dominating damage. The patients were divided into two groups: the main and the control group, using the equal quantitative ratio according to the sex, age, circumstances of trauma and type of damages.

[Principles of early rehabilitation of the neurotrauma].

The retrospective analysis of surgical and rehabilitation treatment of 172 patients with neurotrauma was made. The patients were treated in Russian Polenov Neurosurgical Institute and Municipal hospital of St. Elizabeth in the period since 2009 till 2012.

[Comparative analysis of laboratory methods for differential diagnosis of early HIV infection].

The study deals with the current topical problem in the development of a laboratory algorithm for the detection of early stages of HIV infection and for the creation of a monitoring system on this basis for the spread of drug-resistant HIV-1 strains. The paper presents the results of experimental examination of the most accessible health care methods for the differential diagnosis of early HIV infection, by using the test systems in Russia and gives practical recommendations on their application.

[Totals of the work of neurosurgical service of Saint Petersburg (2000-2006)].

An analysis of work of neurosurgical service in Saint Petersburg for 2000 through 2006 has shown that the state of the system of organization of medical care needs reorganization and higher quality that can be realized by preferable hospitalization of such patients to specialized hospitals with successive treatment and observation of all stages of treatment and united medical strategy.

[Serologic diagnostics of Legionella infection].

Technical approaches to construction of preparations for serologic diagnostics of Legionella infection were presented in the article; antigenic- and immunoglobulin-based diagnostic kits with known characteristics were developed. Immunogenic properties of protein and lypopolysaccharide antigens, which have diagnostic value, were studied; similarity of protein antigens from 7 serogroups of L. pneumophila was demonstrated.

[Quality of life of Saratov region residents with rheumatoid arthritis].

The aim of the study was to evaluate quality of life (QL) of patients with rheumatoid arthritis (RA) in Saratov region. The study was conducted within the framework of the program MCSQL (multi-center study of quality of life). The work presents the results of an investigation of the center of Saratov.

[The epidemiology of injuries to the spine and spinal cord in Saint Petersburg].

The epidemiology of injuries to the spine and spinal cord (ISSC) in Saint Petersburg and its dynamics in 1994 to 1996 were studied. The incidence of ISSC in the city was 0.44 cases per 10,000 (0.

Differential expression of D and R components of Epstein-Barr virus early antigen after superinfection and after induction with 5-iododeoxyuridine.

Three non-productive human lymphoblastoid cell lines, NC-37, RAJI and L-1, either superinfected with Epstein-Barr (EB) virus from P3HR-1 cells or treated with 5-iododexyuridine (IUDR), were studied for the development of early antigen (EA) of EB virus. In all three superinfected cell lines, both the restricted (R) and diffuse (D) componets of EA were synthesized, with R-component formation preceding D-component synthesis. After IUDR treatment both components of EA were only formed in RAJI cells, while in NC37 and L-1 cells only the R-component was synthesized.

Epstein-Barr virus antibodies in tonsillar carcinoma patients;

Sera from 18 tonsillar carcinoma patients and from 18 matched control subjects were examined for the presence of antibodies to viral capsid antigen (VCA), early antigen (EA) and nuclear antigen (EBNA) of EB virus. Antibodies to all three antigens were found more frequently and in significantly higher titres in the tonsillar carcinoma patients than in control subjects.