Publications by authors named "Simonetta Maria Leto"
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Synopsis of recent research by authors named "Simonetta Maria Leto"
- Simonetta Maria Leto's research primarily focuses on the development of innovative therapeutic strategies for colorectal cancer (CRC), specifically targeting mechanisms such as HER2 amplification and telomere maintenance.
- Recent studies highlight a novel combinatorial immunotherapy utilizing synNotch-CAR technology to enhance safety and efficacy by targeting both HER2 and carcinoembryonic antigen (CEA) in CRC with HER2 amplification.
- Her work also emphasizes the importance of patient-derived organoid and cell line models, demonstrating their suitability for preclinical studies by accurately replicating the genetic and microenvironmental complexities of human CRC, thus advancing treatment development.