Publications by authors named "Simoneau J"
Tissue-agnostic, molecularly targeted therapies are becoming increasingly common in cancer treatment. The molecular drivers of some classes and subclasses of tumors are rapidly being uncovered in an era of deep tumor sequencing occurring at the time of diagnosis. When and how targeted therapies should fit within up-front cytotoxic chemotherapy and radiation paradigms is yet to be determined, because many of them have been studied in single-arm studies in patients with relapsed or refractory cancer.
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- Premature infants with bronchopulmonary dysplasia (BPD) are at risk for pulmonary hypertension (PH), and this study explores the connection between patent ductus arteriosus (PDA) management strategies and the prevalence of BPD-PH.
- The research involved examining newborns under 29 weeks gestational age with BPD across two centers—one with a conservative PDA approach and the other with a more aggressive treatment method.
- Findings indicated similar rates of PH between the two centers despite different PDA treatment rates, suggesting that a conservative approach does not increase the likelihood of PH diagnosis in these infants.
The Gottesman-Kitaev-Preskill (GKP) code encodes a logical qubit into a bosonic system with resilience against single-photon loss, the predominant error in most bosonic systems. Here we present experimental results demonstrating quantum error correction of GKP states based on reservoir engineering of a superconducting device. Error correction is made fully autonomous through an unconditional reset of an auxiliary transmon qubit.
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- A study was conducted to explore how the severity of congenital diaphragmatic hernia (CDH) affects patients' perceptions of their quality of life (QOL).
- Researchers used the Pediatric Quality of Life Inventory (PedsQL) to gather data from patients aged 5 and older and found that those with severe CDH reported significantly lower QOL scores, especially in areas like physical activity and social interactions.
- The findings highlight the need for better health monitoring and improvements in care based on patient experiences, particularly for those with severe cases of CDH.
Article Synopsis
- The study aimed to identify specific fetal echocardiography markers that can accurately predict coarctation of the aorta (CoA) in newborns, as current diagnostic methods have a high rate of false positives.
- Researchers conducted a retrospective case-control study comparing various echocardiographic measurements of infants who required treatment for CoA after birth with those who did not, stratifying results based on gestational age (GA).
- Results showed that specific ratios of right to left ventricular dimensions and deformation parameters are the most effective predictors of true CoA, particularly the RV/LV end-diastolic area ratio, which identified all cases of CoA with a high sensitivity.
Heavy menstrual bleeding in adolescents: a primary issue in primary care.
Res Pract Thromb Haemost
November 2023
There is a gap in the literature on the best treatment of clinical sequelae within adolescent and young adult pediatric cancer populations. Children, adolescents, and young adults are at risk for a multitude of immediate and late effects of their disease and treatment that warrant a comprehensive, multidisciplinary team approach to optimize care. Sports medicine providers are well-equipped with their background to join the oncology rehabilitation team in diagnosing and managing cancer-related impairments to help these populations live a healthier and more active lifestyle.
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- - The study investigated how early cardiac function impacts outcomes like death and severe bronchopulmonary dysplasia (BPD) in extremely premature infants born before 29 weeks, through a retrospective analysis of 176 infants from 2015 to 2019.
- - Findings revealed that infants who experienced death/severe BPD had lower birth weights and showed reduced heart function on echocardiograms taken within 21 days, with specific measurements indicating worse cardiac performance and potential pulmonary issues.
- - The research concluded that diminished cardiac function early in life correlates with increased risks of severe BPD and related pulmonary hypertension, suggesting the importance of monitoring heart health in neonates and its potential role in predicting outcomes.
Article Synopsis
- Researchers studied the link between left cardiac 3D echocardiographic measurements and brain injury in newborns with neonatal encephalopathy in a single hospital.
- They found that on the second day of life, babies with brain injury had larger left ventricle end-diastolic volume and stroke volume compared to those without brain injury.
- Additionally, these infants showed a higher peak global circumferential strain on the 3D echocardiogram, suggesting possible cardiac changes associated with brain injury.
Article Synopsis
- The study investigated how the degree of prematurity (specifically the gestational age at birth) affects cardiac size and function in extremely preterm infants at near-term age.
- Researchers analyzed data from infants born at less than 29 weeks of gestational age, comparing those born before and after 26 weeks.
- Results showed that infants born before 26 weeks had significantly smaller left heart dimensions compared to their slightly more mature counterparts, highlighting potential long-term cardiac concerns.
Objective: This study aimed to evaluate the prevalence of adverse outcomes, specifically pulmonary hypertension (PH) and suspected or confirmed necrotizing enterocolitis (NEC), and their associated risk factors, in neonates treated with diazoxide.
Study Design: A retrospective study in infants born ≥ 31 weeks and admitted between January 2014 and June 2020. Combined adverse outcomes possibly associated to diazoxide were PH (systolic pulmonary pressure of ≥40 mm Hg or an eccentricity index ≥1.
Article Synopsis
- The study aimed to compare vascular flow trends in the anterior cerebral artery (ACA) of neonates with congenital heart defects (CHD), focusing on those with and without diastolic systemic steal during their first week of life.
- Researchers used Doppler ultrasound and echocardiography to analyze 38 neonates daily from day 1 to 7, categorizing them based on the presence of retrograde flow in the aorta.
- Results showed that while peak systolic and mean velocities increased over time regardless of retrograde status, those with retrograde flow experienced a significant decrease in ACA-end-diastolic velocity and increases in resistive and pulsatility indexes, indicating cerebrovascular steal in the first week of life.
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- Hypertensive disorders of pregnancy (HDP) are linked to lower platelet counts and higher rates of thrombocytopenia in extremely premature infants (born before 29 weeks), which is important given the potential health implications.
- A study involving 296 infants showed that those exposed to HDP had significantly lower platelet counts and were more likely to require platelet transfusions compared to those not exposed.
- Although low initial platelet counts were associated with severe intraventricular hemorrhage (IVH), they weren't directly tied to exposure to HDP itself.
Article Synopsis
- The study aimed to assess the factors linked to significant pulmonary hypertension (PH) in infants born prematurely and how it affects their heart function at 36 weeks postmenstrual age (PMA).
- Out of 387 infants, 222 were studied, with 24 (11%) showing significant PH, which was linked to lower heart function metrics, including reduced tricuspid annular plane systolic excursion and peak longitudinal strain in both the right and left ventricles.
- The results indicate that premature infants with significant PH experience changes in heart function affecting both sides of the heart, highlighting a deeper cardiac issue related to their PH condition.
Article Synopsis
- * The child's symptoms included high B cell activity, increased eosinophils, and elevated IgE, along with unique findings such as bone marrow reduction and serious inflammation in joints.
- * Treatment with tofacitinib, which targets specific immune signaling pathways, led to significant improvements, emphasizing the importance of thorough genetic assessments for immune-related conditions.
Early Echocardiography Predicts Intervention Need in Antenatal Suspicion of Coarctation of the Aorta.
CJC Pediatr Congenit Heart Dis
August 2022
Article Synopsis
- Coarctation of the aorta (CoA) is tough to spot in newborns, but researchers studied infants suspected of having CoA to understand resource use and intervention needs.
- In a study of 51 infants, only 11 needed cardiac surgery, while 40 were considered normal, with echocardiograms done within the first day of life.
- Key findings suggest that a specific left-to-right ventricular size ratio could effectively predict which infants actually have CoA, helping identify those who need intervention early on.
Article Synopsis
- The study aimed to assess the spontaneous closure of patent ductus arteriosus (PDA) in extremely preterm infants, particularly those born before 26 weeks gestational age, and its impact on their respiratory health.
- A retrospective analysis was conducted on 214 extremely preterm infants admitted shortly after birth, with significant findings showing that 91% experienced spontaneous PDA closure, including 90% of those <26 weeks.
- The results indicated not only high closure rates by term corrected age but also a notable reduction in occurrences of moderate-to-severe bronchopulmonary dysplasia over the study period.
Article Synopsis
- Preterm birth is linked to a higher risk of cardiovascular disease and early death, with evidence indicating changes in left ventricle (LV) structure and function in individuals born preterm.
- A study of 86 young adults born before 30 weeks of gestation found smaller LV dimensions and reduced stroke volume and cardiac output compared to 85 full-term controls.
- While some LV function markers did not differ significantly after accounting for body size, the findings suggest that monitoring these changes could help in preventing cardiovascular issues in those born preterm.
RNA-seq is a modular experimental and computational approach aiming in identifying and quantifying RNA molecules. The modularity of the RNA-seq technology enables adaptation of the protocol to develop new ways to explore RNA biology, but this modularity also brings forth the importance of methodological thoroughness. Liberty of approach comes with the responsibility of choices, and such choices must be informed.
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- Adults born preterm, especially those with bronchopulmonary dysplasia (BPD), show altered right ventricular (RV) systolic function compared to full-term peers, indicating potential heart health issues later in life.
- The study found that significant percentages of preterm individuals, particularly those with BPD, had signs of RV systolic dysfunction, measured by a specific echocardiographic marker.
- Respiratory function was also impacted in preterm individuals, but surprisingly, there was no direct link between respiratory function and RV systolic function, suggesting separate pathways of complications.
Objective: This study was aimed to describe the cardiopulmonary profiles of adult patients with bronchopulmonary dysplasia (BPD), comparing them to normative adult values.
Study Design: This study presents a retrospective chart review of all BPD patients followed in the adult BPD clinic, identified from institutional and archive databases, born preterm at ≤33 weeks of estimated gestational age (EGA) between January 1980 and December 2000.
Results: Forty-four patients with BPD (26.