[Prediction of Return to Work following Multiple Trauma in Patients with ISS of at least 25].

Purpose: Survival rates after severe multiple trauma have continually increased in the last decades. Return to work (RTW) of persons affected by severe multiple trauma is important to assure their quality of life and social participation. Therefore, knowledge about aspects associated with RTW is essential for acute and rehabilitative care and treatment.

Treating patella fractures with a locking patella plate - first clinical results.

The standard treatment for patella fractures is tension band wiring. However, with tension band wiring anatomical reduction and rigid fixation can be challenging and the clinical outcome after patella fracture is often not satisfying. The purpose of this prospective clinical observation was to evaluate the clinical outcome in patients with patella fractures treated with an angular stable patella plate.

Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy.

Background: Non-adherence has been associated with reduced graft survival. The aim of this study was to investigate the immunological mechanisms underlying chronic renal allograft rejection using a model of non-adherence to immunosuppressive therapy. We used a MHC (major histocompatibility complex) -mismatched rat model of renal transplantation (Brown Norway to Lewis), in which rats received daily oral cyclosporine A.

CCR7 Is Important for Mesangial Cell Physiology and Repair.

The homeostatic chemokine receptor CCR7 serves as key molecule in lymphocyte homing into secondary lymphoid tissues. Previous experiments from our group identified CCR7 also to be expressed by human mesangial cells. Exposing cultured human mesangial cells to the receptor ligand CCL21 revealed a positive effect on these cells regarding proliferation, migration, and survival.

Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation.

Objective: Despite substantial progress in recent years, graft survival beyond the first year still requires improvement. Since modern immunosuppression addresses mainly T-cell activation and proliferation, we studied macrophage infiltration into the allografts of 103 kidney transplant recipients during acute antibody and T-cell mediated rejection. Macrophage infiltration was correlated with both graft function and graft survival until month 36 after transplantation.

Biomechanical Assessment of Locked Plating for the Fixation of Patella Fractures.

Objective: To analyze the mechanical stability of locked plating in comparison with tension-band wiring for the fixation of fractures of the patella.

Methods: Biomechanical tests were performed on artificial foam patella specimens comparing an angular stable plate and monocortical screws with tension-band wiring. Tests were performed under combined tension and bending until failure simulating physiological loading of the tibia during walking.

Outcome after severe multiple trauma: a retrospective analysis.

Background: Aim of this study was to evaluate prognosis of severely injured patients.

Methods: All severely injured patients with an Injury Severity Score (ISS) ≥ 50 were identified in a 6-year-period between 2000 and 2005 in German Level 1 Trauma Center Murnau. Data was evaluated from German Trauma Registry and Polytrauma Outcome Chart of the German Society for Trauma Surgery and a personal interview to assess working ability and disability and are presented as average.

The influence of patellar resurfacing on patellar kinetics and retropatellar contact characteristics.

Background: Femoropatellar complications are one of the most common problems after total knee arthroplasty (TKA). However, the question of whether to resurface the patella remains controversial. Therefore, we evaluated the kinetics and the retropatellar contact characteristics of patella resurfacing with fixed and gliding surfaces.

Influence of total knee arthroplasty on patellar kinematics and contact characteristics.

Purpose: Femoro-patellar complications are one of the most common problems after total knee arthroplasty (TKA). TKA components that reduce patellar loads and preserve physiological patellar kinematics should reduce these problems. Therefore, we evaluated the patellar kinematics and the retro-patellar contact characteristics in both the intact knee and in the TKA-knee.