Publications by authors named "Simone V Benatti"

Article Synopsis
  • A multicenter observational study named CONDIVIDIAMO analyzed the effectiveness of monoclonal antibodies (mAbs) in reducing COVID-19 hospitalizations among outpatients with risk factors for severe disease.
  • The study enrolled 1,534 participants and tracked outcomes over 28 days, recording hospitalizations and deaths, with results showing a 5.6% incidence of hospitalization or death after mAbs treatment.
  • Key risk factors identified for increased hospitalization included older age and immunodeficiency, highlighting the importance of targeting vulnerable populations for mAb treatment.
View Article and Find Full Text PDF

Background: Recovery from acute COVID-19 may be slow and incomplete: cases of Post-Acute Sequelae of COVID (PASC) are counted in millions, worldwide. We aimed to explore if and how the pre-existing Socio-economic-status (SES) influences such recovery.

Methods: We analyzed a database of 1536 consecutive patients from the first wave of COVID-19 in Italy (February-September 2020), previously admitted to our referral hospital, and followed-up in a dedicated multidisciplinary intervention.

View Article and Find Full Text PDF

Prevention of infections is crucial in solid organ transplant (SOT) candidates and recipients. These patients are exposed to an increased infectious risk due to previous organ insufficiency and to pharmacologic immunosuppression. Besides infectious-related morbidity and mortality, this vulnerable group of patients is also exposed to the risk of acute decompensation and organ rejection or failure in the pre- and post-transplant period, respectively, since antimicrobial treatments are less effective than in the immunocompetent patients.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated thyroid dysfunction and autoimmune thyroid disease (ATD) in 599 COVID-19 survivors three months after hospital admission, focusing on the prevalence of specific antibodies.
  • Results showed that female sex was positively associated with thyroid autoimmunity, while type 2 diabetes had a negative association; other demographic factors and COVID-19 severity did not impact autoimmunity risk.
  • The prevalence of thyroperoxidase antibodies (TPOAb) in COVID-19 survivors was significantly higher at 15.7% compared to 7.7% in non-thyroid disease controls, and ultrasound revealed thyroiditis in nearly all patients with positive antibodies.
View Article and Find Full Text PDF

Bergamo province was badly hit by the coronavirus disease 2019 (COVID-19) epidemic. We organised a public-funded, multidisciplinary follow-up programme for COVID-19 patients discharged from the emergency department or from the inpatient wards of 'Papa Giovanni XXIII' Hospital, the largest public hospital in the area. As of 31 July, the first 767 patients had completed the first post-discharge multidisciplinary assessment.

View Article and Find Full Text PDF

Background: Patients with multiple sclerosis (MS) are at increased risk of infection. Vaccination can mitigate these risks but only if safe and effective in MS patients, including those taking disease-modifying drugs.

Methods: A modified Delphi consensus process (October 2017-June 2018) was used to develop clinically relevant recommendations for making decisions about vaccinations in patients with MS.

View Article and Find Full Text PDF

One of the most painful aspects of this pandemic is the irremediable separation of patients from their families at the end of their lives.

View Article and Find Full Text PDF

Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic derangement, and the associated injuries.

View Article and Find Full Text PDF

We report safety and tolerability of raltegravir (RAL) as a forth HIV agent in two highly viraemic newborns. Raltegravir (6 mg/kg) was given orally twice daily. The other antiretrovirals were assumed according to standard dose for newborns.

View Article and Find Full Text PDF