Publications by authors named "Simone Soriano"
Introduction: Diverticular disease (DD), commonly associated with the elderly, is becoming more prevalent among younger individuals. This retrospective study aimed to evaluate the differences in the natural history and outcomes between young and old patients with DD.
Methods: Adult patients with DD diagnosed between 2010 and 2022 at an Italian tertiary referral center were enrolled, and their demographic and clinical data were retrieved.
Article Synopsis
- The study investigates the diagnostic delays in patients with symptomatic uncomplicated diverticular disease (SUDD) and identifies associated risk factors over a period from 2010 to 2022.
- A total of 70 patients were analyzed, revealing a median diagnostic delay of 7 months, with 25% initially misdiagnosed with irritable bowel syndrome (IBS).
- Key findings indicated that past misdiagnosis, high educational levels, and prior abdominal surgeries significantly influenced the extent of diagnostic delays in SUDD cases.
Glutathione is a tripeptide synthesized at cytosolic level, that exists in cells in a reduced form (thiol-reduced-GSH-) and in an oxidized form (disulfide-oxidized). The antioxidant function of GSH has led to speculation about its therapeutic role in numerous chronic diseases characterized by altered redox balance and reduced GSH levels, including, for instance, neurodegenerative disorders, cancer, and chronic liver diseases. Among these latter, non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in hepatocytes, in the absence of alcohol abuse or other steatogenic factors, is one of the most prevalent.
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- A study investigated the presence of intraepithelial lymphocyte (IEL) infiltration in patients with potential autoimmune gastritis (AIG) who had positive anti-parietal cell antibodies but no gastric atrophy.
- Nine patients who developed overt AIG were analyzed for deep and superficial CD3+ IEL counts, revealing significantly higher deep IEL counts compared to healthy controls and those with active H. pylori gastritis.
- Results suggest that increased deep CD3+ IEL infiltration could serve as a marker for potential AIG, indicating the need for further studies with more patients to confirm these findings.
Impact of COVID-19 in immunosuppressive drug-naïve autoimmune disorders: Autoimmune gastritis, celiac disease, type 1 diabetes, and autoimmune thyroid disease.
Pediatr Allergy Immunol
January 2022
Few conflicting data are currently available on the risk of SARS-CoV-2 infection in patients with autoimmune disorders. The studies performed so far are influenced, in most cases, by the treatment with immunosuppressive drugs, making it difficult to ascertain the burden of autoimmunity per se. For this reason, herein we assessed the susceptibility to COVID-19 in immunosuppressive drug-naïve patients with autoimmune diseases, such as autoimmune gastritis (AIG), celiac disease (CD), type 1 diabetes (T1D), and autoimmune thyroid disease (AITD).
View Article and Find Full Text PDFLittle is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25-97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome.
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