Top ten priorities for global saltmarsh restoration, conservation and ecosystem service research.

Coastal saltmarshes provide globally important ecosystem services including 'blue carbon' sequestration, flood protection, pollutant remediation, habitat provision and cultural value. Large portions of marshes have been lost or fragmented as a result of land reclamation, embankment construction, and pollution. Sea level rise threatens marsh survival by blocking landward migration where coastlines have been developed.

Economic valuation of wildlife conservation.

Unlabelled: This paper reviews concepts and methods for the economic valuation of nature in the context of wildlife conservation and questions them in light of alternative approaches based on deliberation. Economic valuations have been used to set priorities, consider opportunity costs, assess co-benefits of conservation, support the case for conservation in public awareness and advocacy, and drive novel schemes to change incentives. We discuss the foundational principles of mainstream economic valuation in terms of its assumptions about values, markets, and human behaviour; propose a list of valuation studies in relation to wildlife protection; and explain the methods used.

Integrating ecosystem markets to co-ordinate landscape-scale public benefits from nature.

Ecosystem markets are proliferating around the world in response to increasing demand for climate change mitigation and provision of other public goods. However, this may lead to perverse outcomes, for example where public funding crowds out private investment or different schemes create trade-offs between the ecosystem services they each target. The integration of ecosystem markets could address some of these issues but to date there have been few attempts to do this, and there is limited understanding of either the opportunities or barriers to such integration.

An approach for evaluating the economic impacts of harmful algal blooms: The effects of blooms of toxic Dinophysis spp. on the productivity of Scottish shellfish farms.

Shellfish production is an important activity for the economy of many countries. As well as its direct value, it helps to stabilize communities in rural areas characterized by limited job opportunities. It is also important for consumers who recognize shellfish as a healthy product that gains its nutrition from natural plankton without the need for fertilizers, chemical treatments or other anthropogenic intervention typical of terrestrial agriculture or other marine aquaculture.

The interplay between economics, legislative power and social influence examined through a social-ecological framework for marine ecosystems services.

In the last 15 years, conservation has shifted increasingly towards perspectives based on the instrumental value of nature, where what counts is what provides benefits to humans. The ecosystem services framework embraces this vision of nature through monetary valuation of the environment to correct market failures and government distortions that hinder efficient allocation of public goods, including goods and services provided by biodiversity and ecosystems. The popularity of this approach is reflected in different countries legislation; for instance, US, EU and UK have introduced economic criteria for comparing costs and benefits of environmental policies in protecting ecosystem services.

Assessing the feasibility of carbon payments and Payments for Ecosystem Services to reduce livestock grazing pressure on saltmarshes.

Saltmarshes provide important services including flood control, climate regulation, and provisioning services when grazed by livestock for agriculture and conservation purposes. Grazing diminishes aboveground carbon, creating a trade-off between these two services. Furthermore, saltmarshes are threatened by overgrazing.

Enteric bacteria of food ice and their survival in alcoholic beverages and soft drinks.

This study aimed to evaluate the levels of enteric bacteria in ice cubes produced in different environments (home-made, prepared in bars and pubs with ice machines and produced in industrial plants) and to determine their survival in different alcoholic beverages and soft drinks. Members of the Enterobacteriaceae family were found in almost all samples analysed. All industrial and the majority of home-made samples did not contain coliforms.

Secretion of novel SEL1L endogenous variants is promoted by ER stress/UPR via endosomes and shed vesicles in human cancer cells.

We describe here two novel endogenous variants of the human endoplasmic reticulum (ER) cargo receptor SEL1LA, designated p38 and p28. Biochemical and RNA interference studies in tumorigenic and non-tumorigenic cells indicate that p38 and p28 are N-terminal, ER-anchorless and more stable relative to the canonical transmembrane SEL1LA. P38 is expressed and constitutively secreted, with increase after ER stress, in the KMS11 myeloma line and in the breast cancer lines MCF7 and SKBr3, but not in the non-tumorigenic breast epithelial MCF10A line.

Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate.

SEL1L-A, a transmembrane glycoprotein residing in the endoplasmic reticulum (ER), is a component of the ER-associated degradation (ERAD) pathway. Alternative splicing generates two smaller SEL1L isoforms, -B and -C, that lack the SEL1L-A membrane-spanning region but retain some sel-1-like repeats, known to be involved in multi-protein interactions and signal transduction. In this study the functional characteristics of SEL1L-B and -C were investigated in human cell models.

Autophagy in hematopoietic stem/progenitor cells exposed to heavy metals: Biological implications and toxicological relevance.

The inherent toxicity of many metal compounds, together with their widespread environmental distribution, raises concerns of potential health hazards. Little is known about the impact of these important environmental toxicants on adult stem/progenitor cells, necessary for tissue homeostasis and repair. We recently reported that autophagy is implicated in the response of hematopoietic stem/progenitor cells to toxic concentrations of hexavalent chromium (Cr[VI]) and cadmium (Cd), two well known carcinogenic heavy metal cations.

SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains.

When expressed in the absence of light chains, secretory Ig-micro chains (micro(s)) undergo endoplasmic reticulum associated degradation (ERAD). This process involves the recognition of terminally misfolded or unassembled molecules, their retro-translocation across the ER membrane and ubiquitination for degradation by cytosolic proteasomes. The molecular components of the ERAD pathway and their coordination remain largely unknown.

Autophagy as an ultrastructural marker of heavy metal toxicity in human cord blood hematopoietic stem cells.

Stem cells are a key target of environmental toxicants, but little is known about their toxicological responses. We aimed at developing an in-vitro model based on adult human stem cells to identify biomarkers of heavy metal exposure. To this end we investigated the responses of human CD34+ hematopoietic progenitor cells to hexavalent chromium (Cr[VI]) and cadmium (Cd).