Publications by authors named "Simone Manenti"

Article Synopsis
  • The study investigates how proton therapy combined with hyperthermia using magnetic nanoparticles affects BxPC3 pancreatic cancer cells, with a focus on cellular responses and survival rates.
  • Findings reveal that this combination treatment significantly reduces cell survival compared to proton therapy alone, indicating a possible new effective therapy for pancreatic tumors.
  • Additionally, the presence of magnetic nanoparticles enhances radiosensitization and increases reactive oxygen species production, which contributes to DNA damage and cell death, paving the way for clinical application of this combined therapy.
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A new instrumental neutron activation analysis (INAA) for the simultaneous determination of titanium (TiO) and silica (SiO) dioxide as UV-filters in sunscreens is described. Samples are encapsulated, neutron irradiated (30 s) and after a suitable decay (3 min), the induced Ti (T = 5.76 min) and Al (T = 6.

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The present article describes the decommissioning of a self-shielded 18 MeV medical cyclotron IBA Cyclone 18/9 after 14 years of operation. A Monte Carlo simulation of the possible nuclear reactions was performed in order to plan the decommissioning activities. During the cyclotron dismantling, the activities of the cyclotron components, concrete wall and floor samples were measured.

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Article Synopsis
  • The study focuses on understanding the metabolism of bismuth (Bi) at environmental exposure levels in laboratory animals, highlighting a gap in research since most existing studies examine extreme doses.
  • Rats were injected with a low dose of Bi and the study used advanced techniques to measure Bi concentrations in various biological fluids and tissues.
  • Results indicated that the highest concentrations of Bi were found in the kidneys, followed by other organs, with urine being the main excretion route, and the liver and testis having significant intracellular Bi levels.
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Background: The number of the applications of bismuth (Bi) is rapidly and remarkably increasing, enhancing the chance to increase the levels to which humans are normally daily exposed. The interest to Bi comes also from the potential of Bi-based nanoparticles (BiNPs) for industrial and biomedical purposes. Like other metal-based NPs used in nanomedicine, BiNPs may release ultratrace amounts of Bi ions when injected.

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TiO nanoparticles (TiO NPs) are the nanomaterial most produced as an ultraviolet (UV) filter. However, TiO is a semiconductor and, in nanoparticle size, is a strong photocatalyst, raising concerns about photomutagenesis. Mesoporous silica nanoparticles (MSN) were synthetized incorporating TiO NPs (TiO@MSN) to develop a cosmetic UV filter.

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A combination of carbon ions/photons irradiation and hyperthermia as a novel therapeutic approach for the in-vitro treatment of pancreatic cancer BxPC3 cells is presented. The radiation doses used are 0-2 Gy for carbon ions and 0-7 Gy for 6 MV photons. Hyperthermia is realized via a standard heating bath, assisted by magnetic fluid hyperthermia (MFH) that utilizes magnetic nanoparticles (MNPs) exposed to an alternating magnetic field of amplitude 19.

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The positron emitter Mn is used for the Positron Emission Tomography - PET imaging.In this work we investigate the nuclear reactions for production of Mn and Mn induced by deuteron beams on natural chromium targets at energies up to E = 28 MeV using the stacked-foils activation technique. We calculate the thick target yields for Mn and for the radionuclidic impurity Mn, and we compare the radionuclidic purity of Mn with that achievable in proton activation of Cr.

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Deuteron-induced nuclear reactions for the generation of Pd were investigated using the stacked-foil activation technique on rhodium targets at deuteron energies up to E=33MeV. The excitation functions of the reactions Rh(d,xn)Pd, Rh(d,x)Rh and Rh(d,2p)Ru have been measured, and the Thick-Target Yield for Pd has been calculated.

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(75)Se-selenite transfer was investigated in a phytoplankton-mussel-rat food chain model consisting of Scenedesmus obliquus (Turpin) Kützing, Unio mancus Lamark and Rattus norvegicus Berkenhout. (75)Se-metabolized forms were investigated in order to identify potential critical steps in the food chain, as well as its relative bioavailability looking also at intracellular, cellular and organ partitioning. Tissue and intracellular distribution of (75)Se in mussels fed with (75)Se-S.

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The (75)Se internal bioavailability was investigated in microalgae, mussels and rats as biological experimental models. The (75)Se accumulation from freshwater to microalgae [Scenedesmus obliquus (Turpin) Kützing], from freshwater to mussels (Unio mancus Lamark) and, finally, per os to rats (Rattus norvegicus Berkenhout) was followed using (75)Se-labelled selenite looking at (75)Se uptake, retention, intracellular distribution and binding with cellular biocomplexes. After exposure to 10, 50 and 500 μg Se L(-1), the microalgae showed an inhibitory effect on population growth only at the highest concentration.

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Proton-induced nuclear reactions for generation of (99)Mo and (99m)Tc radionuclides were investigated using the stacked-foil activation technique on 99.05% enriched (100)Mo targets at energies up to Ep=21MeV. Excitation functions of the reactions (100)Mo(p,x)(99)Mo and (100)Mo(p,2n)(99m)Tc have been measured.

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Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the growth curve of the cumulative (direct and indirect) and the direct production of (177g)Lu were determined.

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The objective of this study was to construct a profile of managerial competencies, based on the consensus of nurse coordinators in the field. This study was developed in a philanthropic hospital in São Paulo, following the research-action model, and included 13 nurse coordinators as participants. The data collection was performed using the focal group technique.

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The radionuclides (131)I, (137)Cs and (134)Cs were observed in the Milano region (45°) of Italy early after the nuclear accident in Fukushima, Japan. Increased atmospheric radioactivity was observed on an air filter taken on 30 March 2011, while the maximum activity of 467 μBq m(-3) for (131)I was recorded at April 3-4, 2011. The first evidence of Fukushima fallout was confirmed with (131)I and (137)Cs measured in precipitation at two sampling sites at Milano on 28 March, 2011, with the concentrations of (131)I and (137)Cs in the rainwater equal to 0.

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Deuteron-induced nuclear reactions for generation of no-carrier-added Lu radionuclides were investigated using the stacked-foil activation technique on natural Yb targets at energies up to E(d)=18.18 MeV. Excitation functions of the reactions (nat)Yb(d,xn)(169,170,171,172,173,174g,174m,176m,177g)Lu and (nat)Yb(d,pxn)(169,175,177)Yb have been measured, among them three ((169)Lu, (174m)Lu and (176m)Lu) are reported for the first time.

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