Publications by authors named "Simone Lubowitzki"

Objective: We investigate the prevalence of five affective temperaments (depressive, cyclothymic, hyperthymic, irritable, and anxious) in a large sample of cancer patients and associations of temperament with cancer site as well as the impact of temperament on overall survival of cancer patients.

Methods: Data for this prospective cohort study was collected in the outpatient clinic of a large cancer center. We used the Temperament Evaluation in Memphis, Pisa and San Diego - Münster Version (TEMPS-M) and recorded patient data.

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Background: Patients receiving chemotherapy require ongoing symptom monitoring and management to optimize their outcomes. In recent years, digital remote monitoring interventions have emerged to provide enhanced cancer care delivery experiences to patients and clinicians. However, patient and clinician experiential evaluations of these technologies are rare.

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Background: Interest in the application of predictive risk models (PRMs) in health care to identify people most likely to experience disease and treatment-related complications is increasing. In cancer care, these techniques are focused primarily on the prediction of survival or life-threatening toxicities (eg, febrile neutropenia). Fewer studies focus on the use of PRMs for symptoms or supportive care needs.

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Article Synopsis
  • The study investigates the prevalence of cancer-related fatigue (CRF) among 1,787 outpatient cancer patients, finding that over 90% experience some level of fatigue, with 14.8% suffering from severe fatigue.
  • It identifies significant factors associated with higher CRF levels, such as increased pain and depressive symptoms, and highlights that lifestyle factors like physical activity and being a parent can reduce fatigue.
  • The researchers recommend a comprehensive treatment approach that considers psychosocial, somatic, and lifestyle factors to better address CRF in cancer patients.
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  • The study aimed to assess how the COVID-19 pandemic affected psychological symptoms like anxiety and depression among cancer patients, while also considering their socioeconomic backgrounds.
  • A total of 1,329 patients were evaluated using standard assessments from 2018 to 2022, focusing on the influence of time, income, and education on psychological distress.
  • The results showed that low income significantly increased psychological burden, especially for depressive symptoms, suggesting that socioeconomic factors play a larger role than the pandemic itself in affecting mental health among cancer patients.
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Background: Survival in cancer patients is associated with a multitude of biological, social, and psychological factors. Although it is well established that all these factors add to overall mortality, it is not well understood how the predictive power of these parameters changes in a comprehensive model and over time.

Methods: Patients who attended the authors' outpatient clinic were invited to participate.

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Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, which infects over 90% of the adult human population worldwide. After primary infections, EBV is recurrently reactivating in most adult individuals. It is, however, unclear, why these EBV reactivations progress to EBV Hodgkin (EBVHL) or non-Hodgkin lymphomas (EBVnHL) only in a minority of EBV-infected individuals.

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Background/objective: The aim of the present study was to compare competing psychometric models and analyze measurement invariance of the (HADS) in cancer outpatients.

Method: The sample included 3,260 cancer outpatients. Latent structure of the HADS was analyzed using confirmatory factor analysis (CFA) with robust maximum likelihood estimation (MLR).

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Objective: We aimed to investigate whether (1) psychological and social indicators influence survival in patients diagnosed with cancer or haematologic malignancies when important biological aspects are controlled for, (2) psychological, social and biological indicators can be utilised to design one collated index for survival, usable in clinical practice to identify patients at risk of shorter survival and to improve personalised healthcare provision.

Methods: In this cross-sectional study, 2263 patients with cancer or haematologic malignancies participated. We analysed 15 biological, psychological and social indicators as risk factors for survival with a Cox proportional hazards model.

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Patients with low socioeconomic status (SES) are among the most underserved groups of people regarding cancer care. Analyzing the impact of the coronavirus-induced disease 2019 (COVID-19) pandemic on health care disparities and calling attention to inequalities in cancer care is crucial to justify and initiate adequate countermeasures. We aimed to determine whether the COVID-19 pandemic aggravated health care disparities of cancer outpatients related to their SES and analyzed patient data of the largest university center providing services for patients with hematologic and oncologic disorders in Austria from 2018 to 2021.

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Article Synopsis
  • Personalized medicine seeks to match specific cancer treatments to individual patients based on their tumor characteristics, but current methods only assist less than 10% of patients.
  • A new approach, called single-cell functional precision medicine (scFPM), was tested on 143 patients with aggressive hematologic cancers, where 39% received treatments guided by scFPM results.
  • Results showed that 54% of patients treated according to scFPM experienced improved progression-free survival, with some achieving exceptional responses lasting three times longer than typical, indicating the method's clinical feasibility and effectiveness.
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Objective: To evaluate effects of remote monitoring of adjuvant chemotherapy related side effects via the Advanced Symptom Management System (ASyMS) on symptom burden, quality of life, supportive care needs, anxiety, self-efficacy, and work limitations.

Design: Multicentre, repeated measures, parallel group, evaluator masked, stratified randomised controlled trial.

Setting: Twelve cancer centres in Austria, Greece, Norway, Republic of Ireland, and UK.

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Objective: Pain depicts a severe physical symptom but its relationship to mental health problems is not well studied in cancer patients. The aim of this study was to investigate the prevalence of pain and its correlation with symptoms of post-traumatic stress disorder (PTSD), depression, anxiety and psychological distress in a large sample of cancer patients.

Methods: From 2010 to 2019, cancer patients who received outpatient treatment at the Medical University of Vienna were assessed with the Post-Traumatic Symptom Scale (PTSS-10) and the Hospital Anxiety and Depression Scales.

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Objective: Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder, which might develop after a traumatic event, like cancer diagnosis, and threatens the patient's psychological and/or physiological integrity. Anxiety, depression, and mental distress are known to be common in cancer patients; however, the frequency of PTSD was not investigated thoroughly in this patient group so far. Here, we aim to screen cancer patients for PTSD symptoms and determine a possible correlation with anxiety, depression, and distress.

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