Publications by authors named "Simone Loy"
Atrial fibrillation (AF) is the most prevalent arrhythmia, often caused by myocardial ischemia/infarction (MI). Men have a 1.5× higher prevalence of AF, whereas women show a higher risk for new onset AF after MI.
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- Cardiac electrophysiology involves intricate ion currents in heart cells (cardiomyocytes) that help in generating electrical signals, but other cell types like cardiac macrophages also impact heart rhythm.
- These macrophages come from both embryonic origins and circulating immune cells and can have both antiarrhythmic and proarrhythmic effects through various mechanisms.
- The review highlights different macrophage types in the heart, their interactions with cardiomyocytes, and compares cardiac macrophages across humans, mice, and pigs, discussing the benefits and drawbacks of using these animal models for research on heart rhythm disturbances.
Resident cardiac macrophages have been demonstrated to facilitate the electrical conduction in the heart. The physiologic heart rhythm is initiated by electrical impulses generated in sinoatrial node (SAN) and then conducted to ventricles via atrioventricular node (AVN). To further study the role of resident macrophages in cardiac conduction system, a proper isolation of resident macrophages from SAN and AVN is necessary, but it remains challenging.
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