Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs.

Background: Sirtuins (SIRT) are NAD-dependent deacetylases that are involved in stress response, antioxidative defense, and longevity via posttranslational modifications. SIRT1 directly activates nitric oxide synthase (NOS). Aging is associated with a reduced sirtuin function and reduction of the cofactor NAD.