Publications by authors named "Simone Gieschler"
Molecular imaging: an innovative force in musculoskeletal radiology.
AJR Am J Roentgenol
August 2013
Objective: A review of the innovative role molecular imaging plays in musculoskeletal radiology is provided. Musculoskeletal molecular imaging is under development in four key areas: imaging the activity of osteoblasts and osteoclasts, imaging of molecular and cellular biomarkers of arthritic joint destruction, cellular imaging of osteomyelitis, and imaging generators of musculoskeletal pain.
Conclusion: Together, these applications suggest that next-generation musculoskeletal radiology will facilitate quantitative visualization of molecular and cellular biomarkers, an advancement that appeared futuristic just a decade ago.
Article Synopsis
- The study investigates the biology of transplanted bone grafts, focusing on the early response of blood vessel formation (angiogenesis) in a mouse model.
- Using a transgenic mouse model, researchers employed bioluminescence imaging to track the activity of the VEGF promoter, which showed a 7-day delay before significant expression post-transplantation.
- The research identifies that osteoblastic cells derived from the grafts express VEGF in response to hypoxia and that this process is regulated by specific signaling pathways, providing insights useful for developing advanced bone graft materials.
Voltage-dependent anion channels (VDACs) are critical regulators of outer mitochondrial membrane permeability in eukaryotic cells. VDACs have also been postulated to regulate cell death mechanisms. Erastin, a small molecule quinazolinone that is selectively lethal to tumor cells expressing mutant RAS, has previously been reported as a ligand for hVDAC2.
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