Publications by authors named "Simone Foderaro"
Article Synopsis
- Cancer-secreted extracellular vesicles (EVs) induce a unique type of mesenchymal stem cells (iMSCs) that contribute to therapy resistance in bone cancers like osteosarcoma and multiple myeloma.
- EVs alter the MSC transcriptome and drive the development of iMSCs, which can eliminate the benefits of therapies aimed at reducing metastasis.
- Targeting EV-induced pathways with a combination of drugs has shown promise in overcoming iMSC-induced resistance, providing potential strategies to enhance treatment effectiveness in patients.
Article Synopsis
- * Liquid biopsies detect circulating tumor cells and their genetic material in body fluids like blood, urine, and saliva, showing promise for cancer screening, diagnosis, and monitoring.
- * Despite challenges in standardization, liquid biopsies could improve treatment response predictions and help monitor disease recurrence, with ongoing research into their clinical applications.
Immune checkpoint inhibitors (ICIs) are largely used in the treatment of patients with advanced non-small-cell lung cancer (NSCLC). Novel biomarkers that provide biological information that could be useful for clinical management are needed. In this respect, extracellular vesicles (EV)-associated microRNAs (miRNAs) that are the principal vehicle of intercellular communication may be important sources of biomarkers.
View Article and Find Full Text PDFBone metastases are common in genitourinary cancers, but they are underreported and not well researched. Synchronous bone metastases occur in 1.39-5.
View Article and Find Full Text PDFImmuno-oncology demonstrated substantial efficacy in cancer treatment. Immune-related adverse events (irAEs) can virtually involve every organ, with different incidence depending on the different immune-checkpoint inhibitor. irAEs consequences can range from quality of life worsening and therapy discontinuation to death, if not recognized promptly.
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