Publications by authors named "Simone Cristina Coutinho"
Comparative activity of ertapenem and piperacillin tazobactam in a murine systemic infection model with Bacteroides fragilis and Escherichia coli.
Kênia Valéria Dos Santos Jacques Robert Nicoli Wanderlany Amancio Martins Simone Cristina Coutinho Ana Carolina Morais Apolônio
J Med Microbiol
November 2007
Article Synopsis
- Ertapenem and piperacillin/tazobactam are broad-spectrum beta-lactam antibiotics effective against mixed infections with Bacteroides fragilis and Escherichia coli.
- The study compared their effects on these bacteria by measuring minimum inhibitory concentrations (MIC) and analyzing time-kill kinetics.
- Results indicated that ertapenem was more effective against E. coli, significantly reducing its viability, while piperacillin/tazobactam only impacted B. fragilis and performed similarly to ertapenem in mixed cultures.