Publications by authors named "Simone Braca"
Article Synopsis
- Parkinson's disease (PD) shows similar lifetime and recent headache prevalence rates compared to controls, with no significant differences in tension-type headaches or migraines.
- Patients with migraines and those treated with dopamine agonists (DAs) often experience headache remission after motor symptoms start, while overall mood depression is more severe in PD patients with migraines.
- The study suggests that although headache prevalence in PD aligns with general rates, changes in the dopaminergic system and treatments may influence the course of migraine symptoms.
Background: About 15% to one third of migraineurs experience aura symptoms. Aura is a reversible focal neurological phenomenon involving visual, sensory, speech, and motor symptoms that usually precede migraine pain. Monoclonal antibodies against calcitonin-related peptide (anti- CGRP mAbs) are effective in preventing chronic and episodic migraine, but little is known about their effectiveness on specifically preventing migraine with aura.
View Article and Find Full Text PDFBackground: Idiopathic intracranial hypertension is a disease characterized by increased intracranial cerebrospinal fluid volume and pressure without evidence of other intracranial pathology. Dural sinuses are rigid structures representing a privileged low-pressure intracranial compartment. Rigidity of dural sinus ensures that the large physiologic fluctuations of cerebrospinal fluid pressure associated with postural changes or to Valsalva effect cannot be transmitted to the sinus.
View Article and Find Full Text PDFObjective: To compare the effectiveness and safety of galcanezumab, fremanezumab, and erenumab for the treatment of chronic and episodic migraine, through real-world data.
Background: Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have been tested extensively in several clinical trials for both episodic and chronic migraine, showing high effectiveness, safety, and tolerability; however, there are no prospective real-world studies intending to compare their efficacy and safety.
Methods: This is a prospective observational cohort study comparing the effectiveness and safety profiles of galcanezumab, fremanezumab, and erenumab for the treatment of chronic and episodic migraine.
Article Synopsis
- - Ramsay Hunt syndrome arises from the reactivation of the varicella zoster virus in the facial nerve's geniculate ganglion, and its diagnosis typically relies on a combination of facial paralysis, ear pain, and the presence of vesicles in the ear area.
- - About one-third of patients may experience Ramsay Hunt syndrome without any visible skin eruptions, and some cases can involve multiple cranial nerves beyond just the facial nerve.
- - Effective treatment for VZV reactivation includes antiviral therapy, which can help recover nerve function despite potential complexities in diagnosis when skin lesions are absent.
Background: Vestibular migraine is considered the most common cause of recurrent vertigo for which specific treatments are missing. Monoclonal antibodies against calcitonin gene-related peptide,, are effective in preventing migraine. Since CGRP is also detected in human cochlear and vestibular organs it may also play a role in vestibular physiology.
View Article and Find Full Text PDFBesides representing the place where a migraine attack generates, what is the physiological role of peptidergic control of arteriolar caliber within the trigemino-vascular system? Considering that the shared goal of most human CGRP-based neurosensory systems is the protection from an acute threat, especially if hypoxic, what is the end meaning of a migraine attack? In this paper, we have reviewed available evidence on the possible role of the trigemino-vascular system in maintaining cerebral perfusion pressure homeostasis, despite the large physiological fluctuations in intracranial pressure occurring in daily life activities. In this perspective, the migraine attack is presented as the response to a cerebral hypoxic threat consequent to a deranged intracranial pressure control aimed at generating a temporary withdrawal from the environment with limitation of physical activity, a condition required to promote the restoration of cerebral fluids dynamic balance.
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