Publications by authors named "Simone Baseggio"
Article Synopsis
- Transcription termination is essential for creating proper mRNAs and proteins, but under stress, the transcription process can ignore stop signals, leading to "readthrough" transcripts that extend beyond gene ends.
- A study examining nearly 3000 human transcriptome profiles revealed that 34% of protein-coding genes produce these readthrough transcripts, especially in regions with less transcription activity, inefficient splicing, and more accessible chromatin.
- The findings suggest that these additional transcripts may act as "miRNA sponges," highlighting that transcription readthrough is common in both unhealthy and healthy tissues and could play a significant role in regulating cellular functions.
