Publications by authors named "Simone A Winkler"

The concept of a 2D cylindrical High Pass Ladder (2D c-HPL) is used in the development of this ultra high radio frequency (UHRF) volumetric head coil for 7T tuned at the Larmor frequency of 298 MHz. The architecture of the 2D c-HPL helps to overcome the challenges associated with non-uniform magnetic field distribution. The prototype consists of an individual resonating array of inductance-capacitance (LC) elements and each component is tuned to the precise frequency.

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Recent developments in the field of radiofrequency (RF) coils for magnetic resonance imaging (MRI) offer flexible and patient-friendly solutions. Previously, we demonstrated a proof-of-concept single-element stretchable coil design based on liquid metal and a self-tuning smart geometry. In this work, we numerically analyze and experimentally study a multi-channel stretchable coil array and demonstrate its application in dynamic knee imaging.

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Wearable sensors are rapidly gaining influence in the diagnostics, monitoring, and treatment of disease, thereby improving patient outcomes. In this review, we aim to explore how these advances can be applied to magnetic resonance imaging (MRI). We begin by (i) introducing limitations in current flexible/stretchable RF coils and then move to the broader field of flexible sensor technology to identify translatable technologies.

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Flexible and stretchable radiofrequency coils for magnetic resonance imaging represent an emerging and rapidly growing field. The main advantage of such coil designs is their conformal nature, enabling a closer anatomical fit, patient comfort, and freedom of movement. Previously, we demonstrated a proof-of-concept single element stretchable coil design with a self-tuning smart geometry.

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Background: The development of materials with tailored signal intensity in MR imaging is critically important both for the reduction of signal from non-tissue hardware, as well as for the construction of tissue-mimicking phantoms. Silicone-based phantoms are becoming more popular due to their structural stability, stretchability, longer shelf life, and ease of handling, as well as for their application in dynamic imaging of physiology in motion. Moreover, silicone can be also used for the design of stretchable receive radio-frequency (RF) coils.

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Magnetic resonance imaging (MRI) gradient coils produce acoustic noise due to coil conductor vibrations caused by large Lorentz forces. Accurate sound pressure levels and modeling of heating are essential for the assessment of gradient coil safety. This work reviews the state-of-the-art numerical methods used in accurate gradient coil modeling and prediction of sound pressure levels (SPLs) and temperature rise.

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Lack of a body-sized, bore-mounted, radiofrequency (RF) body coil for ultrahigh field (UHF) magnetic resonance imaging (MRI) is one of the major drawbacks of UHF, hampering the clinical potential of the technology. Transmit field (B ) nonuniformity and low specific absorption rate (SAR) efficiencies in UHF MRI are two challenges to be overcome. To address these problems, and ultimately provide a pathway for the full clinical potential of the modality, we have designed and simulated two-dimensional cylindrical high-pass ladder (2D c-HPL) architectures for clinical bore-size dimensions, and demonstrated a simplified proof of concept with a head-sized prototype at 7 T.

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Article Synopsis
  • Magnetic resonance guided focused ultrasound (MRgFUS) is a non-invasive treatment method for neurodegenerative diseases that combines MRI imaging and ultrasound technology to target specific brain regions effectively.
  • The development of a new 8-channel, flexible head coil called FUS-Flex enhances MRI signal quality by significantly increasing the signal-to-noise ratio (SNR) compared to standard body coils.
  • Initial tests show that the FUS-Flex coil not only improves MRI image quality but also allows for more precise targeting and better monitoring of temperatures during MRgFUS procedures, potentially improving patient outcomes.
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The purpose of this study is to investigate feasibility of estimating the specific absorption rate (SAR) in MRI in real time. To this goal, SAR maps are predicted from 3T- and 7T-simulated magnetic resonance (MR) images in 10 realistic human body models via a convolutional neural network. Two-dimensional (2-D) U-Net architectures with varying contraction layers and different convolutional filters were designed to estimate the SAR distribution in realistic body models.

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Magnetic resonance imaging systems rely on signal detection via radiofrequency coil arrays which, ideally, need to provide both bendability and form-fitting stretchability to conform to the imaging volume. However, most commercial coils are rigid and of fixed size with a substantial mean offset distance of the coil from the anatomy, which compromises the spatial resolution and diagnostic image quality as well as patient comfort. Here, we propose a soft and stretchable receive coil concept based on liquid metal and ultra-stretchable polymer that conforms closely to a desired anatomy.

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In magnetic resonance imaging (MRI), wearable wireless receive coil arrays are a key technology goal. An MRI compatible wireless power transfer (WPT) system will be needed to realize this technology. An MRI WPT system must withstand the extreme electromagnetic environment of the scanner and cannot degrade MRI image quality.

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Background Screen-printed MRI coil technology may reduce the need for bulky and heavy housing of coil electronics and may provide a better fit to patient anatomy to improve coil performance. Purpose To assess the performance and caregiver and clinician acceptance of a pediatric-sized screen-printed flexible MRI coil array as compared with conventional coil technology. Materials and Methods A pediatric-sized 12-channel coil array was designed by using a screen-printing process.

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Purpose: To identify novel concepts for RF-shim loop architectures suitable for 7T made of two concentric conducting loops fulfilling RF and DC functions, respectively, and to determine their relative SNR performance. The goal is to minimize interference between the two systems while making efficient use of the space closest to the body.

Theory: We show by means of theoretical derivation of the frequency spectrum that the proposed two-loop structure exhibits an anti-resonant null and a resonant peak in the frequency domain.

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Ultra High Field (UHF) MRI requires improved gradient and shim performance to fully realize the promised gains (SNR as well as spatial, spectral, diffusion resolution) that higher main magnetic fields offer. Both the more challenging UHF environment by itself, as well as the higher currents used in high performance coils, require a deeper understanding combined with sophisticated engineering modeling and construction, to optimize gradient and shim hardware for safe operation and for highest image quality. This review summarizes the basics of gradient and shim technologies, and outlines a number of UHF-related challenges and solutions.

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Purpose: To accurately analyze vibroacoustics in MR head gradient coils.

Theory And Methods: A detailed theoretical model for gradient coil vibroacoustics, including the first description and modeling of Lorentz damping, is introduced and implemented in a multiphysics software package. Numerical finite-element method simulations were used to establish a highly accurate vibroacoustic model in head gradient coils in detail, including the newly introduced Lorentz damping effect.

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Purpose: To develop a new method capable of directly measuring specific absorption rate (SAR) deposited in tissue using the thermoacoustic signal induced by short radiofrequency (RF) pulse excitation.

Theory: A detailed model based on the thermoacoustic wave generation and propagation is presented.

Methods: We propose a new concept for direct measurement of SAR, to be used as a safety assessment/monitoring tool for MRI.

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Purpose: To improve image contrast and B1+ field homogeneity in 3 Tesla (T) breast MR.

Materials And Methods: Two practical B1+ shimming methods for 3T breast MR are presented; low-cost passive shimming using local pads of high dielectric permittivity (εr from 0 to 100), and two-channel radiofrequency (RF) shimming (adjusting Q-I amplitude ratios and phase differences of 0 to -4 dB and 90 to 45 degrees), as well as a combination of both methods. The technique has been studied both in simulation using a numerical body model with added mammary tissue and in vivo in six subjects.

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