Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in -Mutant Fibroblasts.

Almost half of autosomal recessive early-onset parkinsonism has been associated with mutations in , coding for parkin, which plays an important role in mitochondria function and calcium homeostasis. Cyclic adenosine monophosphate (cAMP) is a major second messenger regulating mitochondrial metabolism, and it is strictly interlocked with calcium homeostasis. -mutant (Pt) fibroblasts, exhibiting defective mitochondrial respiratory/OxPhos activity, showed a significant higher value of basal intracellular level of cAMP, as compared with normal fibroblasts (CTRL).