Digital biomarkers and sex impacts in Alzheimer's disease management - potential utility for innovative 3P medicine approach.

Unlabelled: Digital biomarkers are defined as objective, quantifiable physiological and behavioral data that are collected and measured by means of digital devices. Their use has revolutionized clinical research by enabling high-frequency, longitudinal, and sensitive measurements. In the field of neurodegenerative diseases, an example of a digital biomarker-based technology is instrumental activities of daily living (iADL) digital medical application, a predictive biomarker of conversion from mild cognitive impairment (MCI) due to Alzheimer's disease (AD) to dementia due to AD in individuals aged 55 + .

Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare.

Precision Medicine implies a deep understanding of inter-individual differences in health and disease that are due to genetic and environmental factors. To acquire such understanding there is a need for the implementation of different types of technologies based on artificial intelligence (AI) that enable the identification of biomedically relevant patterns, facilitating progress towards individually tailored preventative and therapeutic interventions. Despite the significant scientific advances achieved so far, most of the currently used biomedical AI technologies do not account for bias detection.

New Titanium Borylimido Compounds: Synthesis, Structure, and Bonding.

We report a combined experimental and computational study of the synthesis and electronic structure of titanium borylimido compounds. Three new synthetic routes to this hitherto almost unknown class of Group 4 imide are presented. The double-deprotonation reaction of the borylamine HNB(NAr'CH) (Ar' = 2,6-CHPr) with Ti(NMe)Cl gave Ti{NB(NAr'CH)}Cl(NHMe), which was easily converted to Ti{NB(NAr'CH)}Cl(py).

New Scandium Borylimido Chemistry: Synthesis, Bonding, and Reactivity.

We report a combined synthetic, mechanistic, and theoretical study of the first borylimido complex of a rare earth metal, (NacNac)Sc{NB(NAr'CH)} (25, Ar' = 2,6-CHPr, NacNac = Ar'NC(Me)CHC(Me)NCHCHNMe). Thermolysis of the methyl-borylamide (NacNac)Sc(Me){NHB(NAr'CH)} (18) generated transient imide 25 via rate-determining, first-order methane elimination (KIE ≈ 8.7).

Reactions of Titanium Hydrazides with Silanes and Boranes: N-N Bond Cleavage and N Atom Functionalization.

Reaction of Ti(N2(iPr)N)(NNPh2)(py) with Ph(R)SiH2 (R = H, Ph) or 9-BBN gave reductive cleavage of the N(α)-N(β) bond and formation of new silyl- or boryl-amido ligands. The corresponding reactions of Cp*Ti{MeC(N(i)Pr)2}(NNR2) (R = Me or Ph) with HBPin or 9-BBN gave borylhydrazido-hydride or borylimido products, respectively. N(α) and N(β) atom transfer and dehydrogenative coupling reactions are also reported.