Characterization of an in vitro model of intestinal cells as a test-bed for mCIPO therapies.

Chronic Intestinal Pseudo-Obstruction in children (CIPO) comprises a group of ultra-rare and debilitating diseases characterized by severe motility defects affecting the entire digestive tract. With limited effective therapies, particularly for myopathic CIPO, we aim at characterizing the behavior of an intestinal smooth muscle cell line undergoing a set of chemical and physical stimulations, to assess their effect. To this end, we adopted healthy Human Intestinal Smooth Muscle Cells, plated on standard coverslips and, for the first time, Micro Electrode Arrays (MEAs).

Effect of Supplementation with a Specific Probiotic ( PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the appearance of recurrent eczematous lesions and intense itching. The World Allergy Organization (WAO) suggested the administration of probiotics in pregnant women at high risk of allergies in their children.

Objectives: Our study aims to evaluate the role of administering the strain PRL2010 during pregnancy and breastfeeding in preventing and/or reducing the severity of AD manifestations in children.