Effect of the flame retardant tris (1,3-dichloro-2-propyl) phosphate (TDCPP) on Na-K-ATPase and Cl transport in HeLa cells.

Tris (1, 3-dichloro-2-propyl) phosphate (TDCPP) is one of the most diffused phosphorus flame retardants in the environment and is highly persistent and abundant in residential dust samples. To date the cellular targets and mechanisms underlying its toxic effects are not completely understood. The aim of this work was to study the effects of TDCPP on ion transport mechanisms fundamental for the cellular ionic homeostasis, such as Na-K-ATPase and Cl transport.