Publications by authors named "Simona Kirdorf"
Int J Cancer
November 2003
Article Synopsis
- HNPCCs, or hereditary nonpolyposis colorectal cancers, are a unique type of colorectal cancer with less aggressive behavior and better prognosis than sporadic cancers.
- Research found that specific matrix metalloproteinases (MMP-1 and MMP-9) and the Ets 1 transcription factor, which are important for tumor invasion, are less expressed in HNPCC tumors compared to sporadic ones.
- These findings suggest that the reduced ability of HNPCC tumors to degrade the surrounding tissue may explain their lower invasiveness and metastatic potential despite their poor differentiation.
