Publications by authors named "Simona Guarino"
Platelet inhibition with orodispersible ticagrelor in acute coronary syndromes according to morphine use: the TASTER study final results.
Eur Heart J Cardiovasc Pharmacother
December 2023
Article Synopsis
- The study aims to investigate whether orodispersible tablet (ODT) ticagrelor can effectively inhibit platelet aggregation in acute coronary syndrome (ACS) patients who are also receiving morphine, comparing it to the standard coated tablet form.
- A total of 130 ACS patients were randomly assigned to receive either ODT or standard ticagrelor loading doses, with assessments made regarding platelet reactivity after treatment, particularly looking for any interaction effects with morphine.
- The results showed that while morphine-treated patients had higher platelet reactivity one hour after the loading dose, there were no significant differences in platelet reactivity between the ODT and standard ticagrelor groups, nor were there significant differences in adverse events related to
Aims: The impact of glucose-6-phosphate dehydrogenase (G6PD) deficiency on coronary atherosclerosis has not been clearly investigated so far. We aimed to assess the effects of G6PD deficiency on the extent and complexity of coronary atherosclerosis in a large unselected cohort of consecutive patients with acute coronary syndromes (ACS).
Methods: We studied 623 consecutive patients presenting with ACS and undergoing coronary angiography and percutaneous coronary intervention (PCI).
Platelet reactivity (PR) has been indicated as a pathophysiological key element for ST-Elevation Myocardial Infarction (STEMI) development. Patients with not-high before-treatment platelet reactivity (NHPR) have been poorly studied so far. The aim of this study is to investigate the prevalence, clinical characteristics, response to therapy and outcomes of baseline prior to treatment NHPR among patients with STEMI undergoing primary PCI.
View Article and Find Full Text PDFThe inability to advance the dedicated wire of the transradial sheath in a radial artery with a good pulsatile blood flow is a very rare event. In this case, the advancement of a high-performance 0.014 inch coronary wire is the only option to gain the vessel.
View Article and Find Full Text PDF