Publications by Simona Debilio

Publications by authors named "Simona Debilio"

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SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.

Pedro Barbosa Liudmila Zhaunova Simona Debilio Verdiana Steccanella Van Kelly

J Cell Biol

February 2021

Meiosis creates genetic diversity by recombination and segregation of chromosomes. The synaptonemal complex assembles during meiotic prophase I and assists faithful exchanges between homologous chromosomes, but how its assembly/disassembly is regulated remains to be understood. Here, we report how two major posttranslational modifications, phosphorylation and ubiquitination, cooperate to promote synaptonemal complex assembly.

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