Publications by authors named "Simona D'Alo'"
Article Synopsis
- - Severe asthma affects roughly 10% of asthma patients and is marked by poor lung function and high eosinophil counts; this study aims to define asthma remission more clearly using a structured method.
- - A panel of experts developed and refined a questionnaire through a two-round Delphi method to evaluate consensus on criteria for asthma remission, including clinical and inflammatory aspects.
- - The analysis confirmed specific criteria for both complete and partial clinical remission, creating a practical tool to assess treatment effectiveness in patients with severe asthma enrolled in the Severe Asthma Network Italy registry.
Background: Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies.
View Article and Find Full Text PDFObjective: The prevalence of asthma in Italy is estimated to be around 4%; it affects approximately 2,000,000 citizens, and up to 80-90% of patients have mild-to-moderate asthma. Despite the clinical relevance of mild-to-moderate asthma, longitudinal observational data are very limited, including data on disease progression (worsening vs. improvement), the response to treatment, and prognosis.
View Article and Find Full Text PDFArticle Synopsis
- * Managing severe asthma should prioritize reducing or stopping oral corticosteroid use, as new biologic treatments have shown effective results, including fewer asthma flare-ups and better symptom control.
- * There is a need to explore alternative treatments for severe asthma before resorting to the frequent use of oral corticosteroids, which should be seen as a last resort.
Background: In the few studies available, the risk of developing systemic reactions (SR) to hymenoptera stings in patients with previous large local reactions (LLRs) to stings ranges from 0 to 7 %. We evaluated both retrospectively and prospectively the risk of SRs in patients with LLRs to stings.
Methods: An overall number of 477 patients, 396 with an SR as the first manifestation of allergy and 81 with a history of only LLRs after hymenoptera stings, were included in the study.
Introduction: Sodium-N-chlorine-p-toluene sulfonamide, commonly known as chloramine-T, is a derivative of chlorine which is widely used as a disinfectant. For many years, chloramine-T has been described as a cause of immediate-type hypersensitivity, especially with regard to asthma and rhinitis, and as a cause of occupational dermatoses in cleaning personnel in hospitals, although no anaphylactic reaction has yet been reported. Hence, to the best of our knowledge we present the first case of anaphylaxis to chloramine-T with evidence of specific immunoglobulin E antibodies.
View Article and Find Full Text PDFAim: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC) from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.
Methods: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS. Control rats received an enema of 0.