Synopsis of recent research by authors named "Simona Aufiero"
- Simona Aufiero's recent research mainly focuses on the roles of RNA-binding proteins, particularly Quaking (QKI) and RBM20, in the regulation of circular RNA (circRNA) production and alternative splicing in cardiomyocytes, indicating their significance in cardiac function and pathology.
- Her studies have demonstrated that QKI governs a muscle-specific alternative splicing program, crucial for defining the contractile properties of cardiomyocytes, as well as exploring how minor intron splicing affects ion channel expression and function.
- In addition to fundamental molecular insights, Aufiero's work also includes applications of artificial intelligence in diagnosing inherited heart disease, aiming to improve clinical recognition and management of conditions such as congenital long QT syndrome.
